54899-73-9

Upstream product

• 529-35-1 5,6,7,8-Tetrahydronaphthalen-1-ol 

Downstream Products

• 89682-89-3 4-bromo-5,6,7,8-tetrahydro-1-benzyloxynaphthalene 
• 675846-24-9 2-(2,5-dimethylpyrrolyl)-6-[4-(2-(dimethylamino)cyclohexyloxy)-5,6,7,8-tetrahydronaphthalen-1-yl]pyridine 
• 221087-87-2 2-(2,5-dimethylpyrrolyl)-6-[4-benzyloxy-5,6,7,8-tetrahydronaphthalen-1-yl]pyridine 
• 221087-85-0 5,6,7,8-tetrahydro-1-benzyloxynaphthalene-4-boronic acid 

Relevant academic research and scientific papers

Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization

An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available dimethyl sulfoxide (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chemistry as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.

Hydrogen bonding and alcohol effects in asymmetric hypervalent iodine catalysis: Enantioselective oxidative dearomatization of phenols

Iodine chooses: A conformationally flexible C2-symmetric organoiodine(III) catalyst for the highly enantioselective catalytic oxidative dearomatization of phenols has been developed. Catalysis is controlled by intramolecular hydrogen-bonding interactions and additional achiral alcohols. Copyright

Chiral anion phase-transfer catalysis applied to the direct enantioselective fluorinative dearomatization of phenols

Chiral anion phase-transfer catalysis has enabled the direct and highly enantioselective fluorinative dearomatization of phenols catalyzed by a BINOL-derived phosphate. The process efficiently transforms simple, readily available phenols into fluorinated chiral small molecules bearing reactive functionality under ambient reaction conditions with high enantioselectivity. The close relationship of the products with well-studied o-quinols provides numerous avenues for synthetic elaboration and exciting opportunities for bioisosteric replacement of hydroxyl with fluorine in natural products.

MODULATORS OF MITOTIC KINASES

The invention relates to compounds of Formula (I), a prodrug, a polymorph, a tautomer, an enantiomer, a stereoisomer, a solvate, an N-oxide, or a pharmaceutically acceptable salt thereof: (formula should be inserted here) which have inhibitory effect on one or more protein kinases that are involved in cell mitosis.

Structure-Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure

The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vivo activity in harmaline-induced cGMP formation in rat cerebellum, a functional model of nNOS inhibition, and in the PCP-induced hypermotility model in the rat. These results suggest that 14bi may be a useful reagent for evaluating potential therapeutic applications of nNOS inhibitors in the central nervous system.

SUBSTITUTED PYRAZINE DERIVATIVES

The present invention provides substituted pyrazine derivatives of Formula (I), that are CRF1 receptor antagonists, including human CRF1 receptors. This invention also relates to use of compounds of the invention for treating a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders, particularly anxiety-related disorders and mood disorders.

Carbamate pesticidal compositions

4-Substituted-5,6,7,8-tetrahydro-1-naphthyl-N-methylcarbamates have been found to exhibit exceptional insecticidal activity.