5490-27-7

Basic information

• Product Name: Dihydrostreptomycin sulfate
• Synonyms: D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)-, sulfate (2:3) (salt);dihydrostreptomycin solution;DIHYDROSTREPTOMYCINSULPHATE(INJ.);DIHYDROSTREPTOMYCINSULPHATE(ORAL);Dihydrostreptomycin sulfate;Prestwick_173;Dihydrostreptomycin Sulfate (200 mg);Double-Mycin
• CAS NO: 5490-27-7
• Molecular Formula: 2C₂₁H₄₁N₇O₁₂*3H₂O₄S
• Molecular Weight: 1451.38
• EINECS: 226-823-7
• Product Categories: PHARMACEUTICALS;A - KAntibiotics;AminoglycosidesAntibiotics;Antibiotics A-FAntibiotics;Antibiotics by Application;AntimycobacterialAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisMore...Close...;Mechanism of Action;Antibacterial;Antibiotics A to;Spectrum of Activity;Agro-Products;Amines;Carbohydrates & Derivatives;Intermediates & Fine Chemicals
• Mol File: 5490-27-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 954.5 °C at 760 mmHg
• Flash Point: 531.1 °C
• Appearance: white to light yellow/crystalline
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: 50 mg/mL, clear, faintly yellow
• Water Solubility: Soluble in water
• Merck: 13,3201
• BRN: 3894221
• CAS DataBase Reference: Dihydrostreptomycin sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydrostreptomycin sulfate(5490-27-7)
• EPA Substance Registry System: Dihydrostreptomycin sulfate(5490-27-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: WK2236000
• TSCA: Yes
• Hazardous Substances Data: 5490-27-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 5490-27-7 differently. You can refer to the following data:
1. Dihydrostreptomycin sesquisulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.
2. As a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.

Therapeutic Function

Antibiotic

Purification Methods

It crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.]

InChI:InChI=1/2C21H41N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1