54903-86-5

Usage

Chemical Properties

White powder

InChI:InChI=1/C5H6BrN3/c6-3-1-2-4(7)9-5(3)8/h1-2H,(H4,7,8,9)

Upstream product

• 2402-92-8 2,3,6-tribromopyridine 
• 5441-02-1 N,N'-(2,6-pyridinediyl)bis(acetamide) 
• 141-86-6 2.6-diaminopyridine 

Downstream Products

• 141-86-6 2.6-diaminopyridine 
• 1345118-98-0 N-[6-amino-5-(3-(2-furyl)-1-methylpyrazol-5-yl)(2-pyridyl)](2-fluorophenyl)carboxamide 
• 1345118-50-4 N-[6-amino-5-(1-methyl-3-phenylpyrazol-5-yl)(2-pyridyl)](2-fluorophenyl)carboxamide 
• 1345118-40-2 2-amino-6-(2-fluorophenyl)carbonylamino-pyridin-3-yl boronic acid 
• 1345118-36-6 N-[6-amino-5-(6-chloro-2,2-difluorobenzo[d]1,3-dioxolen-5-yl)(2-pyridyl)](2-fluorophenyl)carboxamide 
• 1345118-38-8 N-(6-amino-5-bromo(2-pyridyl))(2-fluorophenyl)carboxamide 
• 1079402-04-2 3-(2,3-dichlorophenyl)pyridine-2,6-diamine 
• 80392-79-6 3-bromo-2,6-difluoro-pyridine 

Relevant academic research and scientific papers

SMALL MOLECULE MODULATORS OF IL-17

The present invention relates to a compound according to formula (I), (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

NEW DEVELOPMENTS IN THE SYNTHESIS OF LOWER FLUORINATED PYRIDINES VIA DIAZOTIZATION-FLUORINATION OF AMINOPYRIDINES IN ANHYDROUS HYDROGEN FLUORIDE

The isolation and stabilization of elusive 4-fluoropyridine as the hydrochloride salt (54percent yield) from fluorodediazoniation of 4-aminopyridine in anhydrous hydrogen fluoride (AHF) is described.Unlike the low yields (0-13percent) recently reported from the chlorodediazoniation of 2,6-diaminopyridine and 3-halo-2,6-diaminopyridine, fluorodediazoniation gave high yields (49-62percent) of the corresponding 2,6-difluoropyridines.In contrast, benzene analogs, i.e. m-phenylenediamine and 4-chloro-m-phenylenediamine, form only tars under similar fluorination conditions.Vicinal aminohalopyridines, e.g. 3-amino-2-chloropyridine and 2-amino-3,5-dichloropyridine give the corresponding fluorohalopyridine in 49-89percent yield.Again, the benzene analogs, i.e. o-chloroaniline and 2,4-dichloroaniline, resist fluorination.

A Convenient Synthesis of 2,3,5,6-Tetrahalogenopyridines and of 3,5-Bis(alkylthio)pyridines from 2,6-Diaminopyridine

Controlled chlorination of 2,6-diaminopyridine (1) affords 2,6-diamino-3,5-dichloropyridine (2a) which is then bis(diazotised) to give 2,3,5,6-tetrachloropyridine (3a); similarly prepared are other 2,3,5,6-tetra(chloro/bromo) pyridines and 2,6-dichloro-3,5-bis(thiocyanato)pyridine (3h), from which 3,5-bis(alkylthio)pyridines are easily obtained.