54904-03-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-N-phenyl-2-pyridinamine is used as a key intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the development of new medications with diverse therapeutic profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-N-phenyl-2-pyridinamine is utilized as a precursor in the production of agrochemicals, playing a crucial role in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Organic Materials Industry:
5-Bromo-N-phenyl-2-pyridinamine is employed as a component in the formulation of various organic materials, leveraging its chemical properties to improve the performance characteristics of these materials in different applications.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 62-53-3 aniline 
• 109-04-6 2-bromo-pyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 2402-97-3 3-bromopyridine N-oxide 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 942050-71-7 5-bromo-N-(2-nitrophenyl)pyridin-2-amine 

Relevant academic research and scientific papers

Iridium(III)-Catalyzed Tandem Annulation of Pyridine-Substituted Anilines and α-Cl Ketones for Obtaining 2-Arylindoles

A facile and expeditious protocol for the synthesis of 2-arylindole compounds from readily available N-(2-pyridyl)anilines and commercially available α-Cl ketones through iridium-catalyzed C-H activation and cyclization is reported here. As a complementary approach to the conventional strategies for indole synthesis, the transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds with good to excellent yields under mild conditions, providing a straightforward method to obtain structurally diverse and valuable indole scaffolds. Furthermore, the reaction could be easily scaled up to gram scale.

Ruthenium-catalyzed synthesis of indole derivatives from: N -aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides

Indole is a ubiquitous structural motif with important applications in many areas of chemistry. Given this, a simple and efficient Ru(ii)-catalyzed synthesis of indole via intermolecular annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed. This protocol provides easy access to a wide variety of useful indoles in the presence of a commercially available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks.

Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines

A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1′-bis[bis(dimethylamino)phosphino]ferrocene "DMAPF", a readily available yet previously unutilized diphosphine, as a uniquely effective ligand for this transformation.

Reaction of Aromatic N-Oxides with Dipolarophiles. VII. Effect of Aromaticity on 1,3-Dipolar Cycloaddition Reactivity of Substituted Pyridine N-Oxides and Preparation of Oxazolopyridine Derivatives

The 1,3-dipolar cycloaddition reactivity of pyridine N-oxides to phenyl isocyanate was calculated by the MINDO/3 MO method using the perturbation equation derived by Klopman and Salem.The calculated did not predict the low reactivity of acceptor substitut