54911-84-1Relevant academic research and scientific papers
Regioselective Alkylation of 2-Trimethylsiloxyfuran; Direct Access to 4-Substituted But-2-en-4-olides
Jefford, Charles W.,Sledeski, Adam W.,Boukouvalas, John
, p. 364 - 365 (2007/10/02)
Primary iodides alkylate 2-trimethylsiloxyfuran in the presence of a molar excess of silver trifluoroacetate to give the 4-alkylbut-2-en-4-olides in 55-81percent yield; as an illustration of the method, the cytotoxic marine sponge constituent, 4-(methoxycarbonylmethyl)but-2-en-4-olide was prepared in 79percent yield in one step.
