54918-89-7Relevant academic research and scientific papers
Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles
Plech, Tomasz,Kaproń, Barbara,Paneth, Agata,Wujec, Monika,Czarnomysy, Robert,Bielawska, Anna,Bielawski, Krzysztof,Trotsko, Nazar,Ku?mierz, Edyta,Paneth, Piotr
, p. 1021 - 1026 (2015)
A series of six 2,5-disubstituted 1,3,4-thiadiazole derivatives was synthesized and examined for cytotoxic activity in MCF-7 and MDA-MB-231 breast cancer cells. MTT assay confirmed that 2-(3-fluorophenylamino)-5-(3-hydroxyphenyl)-1,3,4-thiadiazole (2), 2-
Potential Anticancer Agents against Melanoma Cells Based on an As-Synthesized Thiosemicarbazide Derivative
Cz?apski, Micha?,Fornal, Emilia,Hawry?, Anna,Iwan, Magdalena,Karczmarzyk, Zbigniew,Korga-Plewko, Agnieszka,Kozyra, Pawe?,Ostrowska-Le?ko, Marta,Pitucha, Monika,Wysocki, Waldemar
, (2022/01/20)
In this paper, thiosemicarbazide derivatives were synthesized as potential anticancer agents. X-ray investigations for 1-(2,4-dichlorophenoxy)acetyl-4-(2-fluorophenyl) thiosemicarbazide, 1-(2,4-dichlorophenoxy)acetyl-4-(4-metylothiophenyl)thiosemicarbazid
Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening
Ali, Yakub,Alam, Mohammad Sarwar,Hamid, Hinna,Husain, Asif,Dhulap, Abhijeet,Bano, Sameena,Kharbanda, Chetna
, p. 1017 - 1025 (2017/09/30)
A library of fourteen 2-imino-4-thiazolidinone derivatives (1a-1n) has been synthesized and evaluated for in vivo anti-inflammatory activity and effect on ex-vivo COX-2 and TNF–α expression. Compounds 1k (5-(2,4-dichloro-phenooxy)-acetic acid (3-benzyl-4-oxo-thiazolidin-2-ylidene)-hydrazide) and 1m (5-(2,4-dichloro-phenooxy)-acetic acid (3-cyclohexyl-4-oxo-thiazolidin-2-ylidene)-hydrazide) exhibited in vivo inhibition of 81.14% and 78.80% respectively after 5 h in comparison to indomethacin which showed 76.36% inhibition of inflammation without causing any damage to the stomach. Compound 1k showed a reduction of 68.32% in the level of COX-2 as compared to the indomethacin which exhibited 66.23% inhibition of COX-2. The selectivity index of compound 1k was found to be 29.00 in comparison to indomethacin showing selectivity index of 0.476. Compounds 1k and 1m were also found to significantly suppress TNF-α concentration to 70.10% and 68.43% in comparison to indomethacin which exhibited 66.45% suppression.
Antihemolytic and anticonvulsant activities of 1 (2,4 dichloro/2,4,5 trichlorophenoxyacetyl) 4 alkyl/arylthiosemicarbazides and their inhibition of NAD dependent oxidations and monoamine oxidase
Ali,Kumar,Parmar,Dwivedi,Harbison
, p. 1329 - 1333 (2007/10/09)
Several 1 (2,4 dichloro and 2,4,5 trichlorophenoxyacetyl) 4 alkyl/arylthiosemicarbazides were synthesized and characterized by their sharp melting points and elemental analyses. All substituted thiosemicarbazides protected in vitro hypoosmotic hemolysis o
