54920-84-2 Usage
Uses
Used in Pharmaceutical Industry:
1,7-Naphthyridin-2-amine is used as an intermediate in the synthesis of various drugs and active pharmaceutical ingredients. Its unique structure and reactivity contribute to the development of new medications with potential therapeutic benefits.
Used in Organic Synthesis:
1,7-Naphthyridin-2-amine serves as a building block in organic synthesis, enabling the preparation of other chemical compounds. Its versatility in chemical reactions allows for the creation of a wide range of molecules with diverse applications.
Used in Medicinal Chemistry and Drug Discovery:
Due to its distinctive structural features and chemical properties, 1,7-Naphthyridin-2-amine has potential applications in medicinal chemistry and drug discovery. Researchers can leverage its reactivity to design and develop novel therapeutic agents with improved efficacy and selectivity.
It is crucial to handle 1,7-Naphthyridin-2-amine with care and adhere to proper safety guidelines when working with it in a laboratory setting to ensure the safety of researchers and the integrity of experiments.
Check Digit Verification of cas no
The CAS Registry Mumber 54920-84-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,9,2 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 54920-84:
(7*5)+(6*4)+(5*9)+(4*2)+(3*0)+(2*8)+(1*4)=132
132 % 10 = 2
So 54920-84-2 is a valid CAS Registry Number.
54920-84-2Relevant academic research and scientific papers
Chichibabin Amination of 1,X-Naphthyridines. Nuclear Magnetic Resonance Studies on the ? Adducts of Heterocyclic Systems with Nucleophiles
Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van
, p. 2134 - 2137 (2007/10/02)
In the amination of 1,X-naphthyridines with potassium amide in liquid ammonia at about -35 to -40 deg C the initial adduct formation is charge controlled.Thus, at these temperatures the site with the lowest electron density is most susceptible for amide attack (C-2 in 1,5-naphthyridine, C-2 in 1,6-naphthyridine, C-2 and C-8 in 1,7-naphthyridine, and C-2 in 1,8-naphthyridine), as proven by NMR spectroscopy.When the temperature was raised to about 10 deg C, the site of addition has been found to change for 1,5- and 1,7-naphthyridine (NMR spectroscopy): from C-2 to C-4 in 1,5-naphthyridine and from C-2 and C-8 to C-8 only in 1,7-naphthyridine.In case of 1,6- and 1,8-naphthyridines no change was observed.Thus, the amination at about 10 deg C is a process which is thermodynamically controlled.The several factors which contribute to the stability of these addition products have been discussed.It has been found that the anionic ? adducts 2(4,8)-aminodihydro-1,X-naphthyridinides can be easily oxidized with potassium permanganate into their corresponding 2(4,8)-amino-1,X-naphthyridines.
