54921-75-4Relevant academic research and scientific papers
Niobium Pentachloride Mediated (Hetero)aromatic Aldehyde Friedel-Crafts Hydroxyalkylation with Arenes: An Efficient Strategy to Synthesize Triarylmethanes
Baviera, Giovanni S.,Donate, Paulo M.,Matias, Alexandre A.,Previdi, Daniel,Rodrigues, Shirley M. M.
, p. 4498 - 4506 (2019/11/21)
Niobium pentachloride is an efficient and useful Lewis acid to conduct Friedel-Crafts hydroxyalkylation between arenes and (hetero)aromatic aldehydes, to generate triarylmethanes. This practical methodology offers several advantages, such as short reaction time, mild experimental conditions, and excellent yields.
Green synthesis and antiviral activity of novel triarylmethane derivatives via Friedel-Crafts alkylation by polyethylene glycol (PEG-400)
Revaprasadu,Sampath,Harika
, p. 473 - 478 (2016/01/20)
A series of novel triarylmethane derivatives (3a-j) were synthesized by a one-pot, two-component method via Friedel-Crafts alkylation of various electron-rich arenes (1a-j) with a wide variety of aldehydes (2a-j) in presence of the polyethylene glycol (PEG-400) as a green solvent at 50-60 °C in good to excellent yields (76-96 %). Their structures were confirmed by FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. All the triarylmethanes were tested and evaluated for their antiviral and antifungal activities. Compounds 3b, 3f, 3g and 3i exhibited highest antiviral activities against tobacco mosaic virus (TMV).
Novel and highly efficient one pot protocol for the synthesis of diversely functionalized triarylmethanes
Babu, B. Madhu,Thakur, Pramod B.,Bangade, Vikas M.,Meshram
supporting information, p. 766 - 771 (2015/02/19)
An efficient, convenient, and novel one pot approach is described for the synthesis of triarylmethanes by in situ oxidation of benzylalcohols followed by the Friedel-Crafts alkylation of di/trimethoxybenzenes in the presence of BF3·OEt2. The generality of the present method is strengthened by screening a variety of aromatic, aliphatic, and heteroaromatic alcohols with methoxy arenes. Shorter reaction time, mild reaction condition, good yields, and wide scope of substrates are the significant features of this protocol.
