54924-33-3

Usage

Uses

Used in Pharmaceutical Research and Development:
(4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL is used as a key intermediate in the synthesis of drugs and bioactive molecules, contributing to the development of new therapeutic agents.
Used in the Treatment of Neurological and Psychiatric Disorders:
In the field of medicine, (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL is used as a potential therapeutic agent for various neurological and psychiatric disorders. Its ability to interact with specific receptors and enzymes in the brain positions it as a candidate for treating such conditions.
Used in Drug Discovery and Development:
(4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL is utilized in the synthesis of novel chemical entities, playing a crucial role in drug discovery and development processes to identify new pharmaceutical compounds with potential therapeutic benefits.

InChI:InChI=1/C12H16FNO/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-4,10,12,14-15H,5-8H2

Upstream product

• 41538-36-7 4-(4-fluorobenzoyl)pyridine 

Downstream Products

• 92822-02-1 4-(4-fluorobenzyl)piperidine 
• 478537-30-3 [1-(3-amino-3-phenyl-propyl)-piperidin-4-yl]-(4-fluoro-phenyl)-methanol 
• 124931-44-8 1-(4-fluorophenyl)-2-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]-ethanone 
• 1600520-84-0 C₂₀H₂₃FN₂O₃ 
• 135256-97-2 1-(4-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone 

Relevant academic research and scientific papers

Synthesis, Calcium-Channel-Blocking Activity, and Antihypertensive Activity of 4-(Diarylmethyl)-1-piperidines and Structurally Related

A series of 4-(diarylmethyl)-1-piperidines and structurally related compounds were synthesized as calcium-channel blockers and antihypertensive agents.Compounds were evaluated for calcium-channel-blocking activity by determineng their ability to antagonize calcium-induced contractions of isolated rabbit aortic strips.The most potent compounds were those with fluoro substituents in the 3- and/or 4-positions of both rings of the diphenylmethyl group.Bis(4-fluorophenyl)acetonitrile analogue 79 was similar in potency to bis(4-fluorophenyl)methyl compound 1.The methylene analogue of 1 (78) and derivatives of 1 that contained a hydroxyl (76), carbamoyl (80), amino (81), or acetamido (82) substituent on the methyl group were less potent.In most cases substituents on the phenoxy ring, changes in the distance between the aryloxy group and the piperidine nitrogen, and the substitution of S, N(CH3), or CH2 for the oxygen atom of the aryloxy group had only a small to moderate effect on the potency.The best compounds in this series were more potent than verapamil, diltiazem, flunarizine, and lidoflazine, but were less potent than nifedipine.Compounds were evaluated for antihypertensive activity in spontaneusly hypertensive rats (SHR) at an oral dose of 30 mg/kg.Of the 55 compounds tested, only nine produced a statistically significant (p-1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (63), which produced a 35percent reduction in blood pressure and was similar in activity to nifedipine.At lower doses, however, 4--1-piperidine (93) was one of the most effective antihypertensive agents, producing reductions in blood pressure of 17 and 11percent at oral doses of 10 and 3 mg/kg, respectively; 63 was inactive at 10 mg/kg.