549474-50-2Relevant academic research and scientific papers
Anti-inflammatory activity of some novel α-amino naphthalene derivatives
Sharma, Shalabh,Srivastava, Virendra Kishore,Kumar, Ashok
, p. 44 - 52 (2007/10/03)
α-Acetylamino naphthalene (1) was reacted with different aromatic aldehydes and with primary or secondary amines to give α-aminonaphthylsubstitutedaryl chalkones (2-5) and α-(substituted aminoethyl)-amidonaphthalenes (14-25), respectively. These substituted chalkones were treated with hydrazinehydrate and hydroxylamine hydrochloride to give 1-acetyl-5-substitutedaryl-3-(α-aminonaphthyl)-2-pyrazolines (6-9)0000000000000000000000000000000 and α-(2-substitutedaryl-isoxazolin-4-yl)-aminonaphthalenes (10-13), respectively. Their chemical structures were confirmed by IR and 1H-NMR spectral data and elemental analysis. Studies of the anti-inflammatory and ulcerogenic activities and acute toxicity of these newly synthesized compounds were performed in vivo and compared with the standard drug, phenylbutazone (CAS 50-33-9). Some of these compounds showed potent anti-inflammatory activity and less ulcerogenic effects than phenylbutazone.
