549503-37-9

Basic information

• Product Name: N-hexyl-3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine
• Synonyms: N-hexyl-3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine
• CAS NO: 549503-37-9
• Molecular Weight: 591.985
• Mol File: 549503-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-hexyl-3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-hexyl-3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine(549503-37-9)
• EPA Substance Registry System: N-hexyl-3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine(549503-37-9)

Safety Data

• Hazardous Substances Data: 549503-37-9(Hazardous Substances Data)

Upstream product

• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 
• 106-41-2 4-bromo-phenol 
• 638-45-9 1-Iodohexane 
• 549503-44-8 3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine 

Relevant articles and documents

N-(alkyl)-2-amino-1,4-pyrazine derivatives: Synthesis and antioxidative properties of 3- and 3,5-p-hydroxyphenyl-substituted compounds

2-Amino-5-(p-hydroxyphenyl)-1,4-pyrazine and 2-amino-3,5-bis(p-hydroxyphenyl)-1,4-pyrazine are endowed with excellent antioxidative properties. For a possible development in medicinal chemistry, the lipophilicity of these lead compounds has to be increased. Therefore various methods of N-alkylation were systematically explored. The best results were obtained by quenching aminopyrazinyl anion with alkyl iodides, and by coupling aldehydes (reductive amination) in the presence of phenylsilane and tin catalyst. Aminopyrazines equipped with linear alkyl side-chains of at least six carbons showed improved radical-scavenging properties in lipidic media.