54952-08-8Relevant academic research and scientific papers
Synthesis of analogues of ochratoxin A
Plastina, Pierluigi,Fazio, Alessia,Attya, Mohamed,Sindona, Giovanni,Gabriele, Bartolo
, p. 1799 - 1805 (2020/03/18)
Four analogues of ochratoxin A (OTA) differing for the aminoacidic moiety were synthesised using ochratoxin (OTα) as the starting material. The condensation reaction between protected amino acids and OT, carried out in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC?HCl) and N-hydroxybenzotriazole (HOBt) as coupling agents, followed by deprotection and PTLC purification afforded OTA alanine, leucine, serine and tryptophane analogues in satisfactory yields (33-47%, based on OT).
