549531-10-4

Usage

Uses

Used in Pharmaceutical Industry:
Tiagabine is used as an antiepileptic medication for the treatment of epilepsy. It is particularly effective in reducing the frequency and severity of seizures by increasing the levels of GABA in the brain, which helps to inhibit excessive neuronal activity.
Used in Neurological Treatments:
In the field of neurology, tiagabine serves as a valuable therapeutic agent for patients with epilepsy, providing an additional option for seizure management alongside other antiepileptic drugs. Its mechanism of action, which involves the enhancement of GABAergic neurotransmission, makes it a useful adjunct in the treatment of various seizure types.

Upstream product

• 92235-34-2 (2-oxopyrrolidin-3-(S)-yl)carbamic acid tert-butyl ester 
• 74-88-4 methyl iodide 
• 5241-66-7 (R)-N-(tert-butoxycarbonyl)methionine 

Relevant academic research and scientific papers

SUBSTITUTED 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES

The present invention provides a compound of Formula (I) wherein R is (II) or (III), or a pharmaceutically acceptable salt thereof, useful for treating psoriasis, systemic lupus erythematosus, or type 1 diabetes.

7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE COMPOUNDS

The present invention provides a compound of Formula (I) wherein R is (II), (III), (IV) or a pharmaceutically acceptable salt thereof, useful for treating psoriasis, systemic lupus erythematosus, or type 1 diabetes.

PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS

The present invention provides a compound of Formula I: wherein R is methyl or ethyl; or a pharmaceutically acceptable salt thereof useful for treating psoriasis or systemic lupus erythematosus.

7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES

The present invention provides a compound of Formula (I) wherein R is (II) or (III); or a pharmaceutically acceptable salt thereof, useful for treating psoriasis or systemic lupus erythematosus.

P38 INHIBITORS AND METHODS OF USE THEREOF

Compounds of formula (I): in which A, B, X, Ar1, R8 and R4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.