549532-35-6

Upstream product

• 111-25-1 1-bromo-hexane 
• 549532-36-7 ethyl (2S)-2-ethoxy-3-(4-{2-[hexyl-(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoate 

Downstream Products

• 810676-88-1 (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid (1R,2S)-2-hydroxyindan-1-amine salt 
• 892402-12-9 (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid tris(hydroxymethyl)methylamine salt 
• 810676-93-8 (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid N-benzyl-2-pnehylethanaminium salt 
• 810676-90-5 (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid tert-butylamine salt 

Relevant academic research and scientific papers

A PHARMACEUTICAL COMPOSITION COMPRISING A SUBSTITUTED PHENYLPROPIONIC ACID AS A FREE ACID AND AS TERT-BUTYL AMINE SALT THEREOF

A pharmaceutical composition comprising a compound of formula I wherein n is 1 or 2, R1 represents hydrogen, chloro, trifluoromethyl or trifluoromethoxy, R2 represents hydrogen or fluoro and R3 represents a C2-6alkyl group, wherein the compound of formula (I) is present in the composition as a free acid and as a tert-butyl amine salt thereof.

TRI (HYDROXYMETHYL) METHYLAMINE SALT OR AN ETHANOL AMINE SALT OF (2S) -2-ETHOXY-3- (4-{2- [HEXYL (2- PHENYLETHYL) AMINO] - 2 -OXOETHOXY} PHENYL) PROPANOIC ACID

The invention relates to a compound selected from one or more of the following: a tris (hydroxymethyl) methylamine salt of (2S)-2- ethoxy-3-(4-{2- [hexyl (2-phenylethyl) amino]-2- oxoethoxy} phenyl) propanoic acid; an ethanol amine salt of (2S)-2-ethoxy-3- (4-{2-[hexyl (2-phenylethyl) amino]-2-oxoethoxy} phenyl) propanoic acid; or a pharmaeutical composition comprising the compound.

Therapeutic agents

The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.

PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES

A calcium or a magnesium salt of (2S)-2-ethoxy-3-(4-{2[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.

PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES

A compound selected from one or more of the following: a ( 1R,2S)-2-hydroxyindan-1-amine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an L-arginine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a tert-butylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a choline salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an adamantylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N-benzyl-2-phenylethanaminium salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; aN-benzyl-2-(benzylamino) ethanaminium salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; or a tris(hydroxymethyl)methylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.

PROCESSES FOR PREPARING (2S)-3-(4-{2-[AMINO]-2-OXOETHOXY}PHENYL)-2-ETHOXYPROPANOIC ACID DERIVATIVES

The present invention provides a process for the preparation of a compound of formula I [Chemical formula should be inserted here. Please see paper copy] in which a compound of formula II [Chemical formula should be inserted here. Please see paper copy] in which R is H or OR represents a protecting group for a carboxylic hydroxy group is reacted with a compound of formula III C6H13X wherein X is a leaving group, in the presence of a base in the presence of an inert solvent at a temperature in the range -25°C to 150°C and optionally, when OR represents a protecting group, removal of the protecting group.