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Usage

Uses

Used in Rubber Industry:
N-Nitroso-N-cyclohexylaniline is used as a rubber antioxidant and antiozonant additive to enhance the durability and lifespan of rubber products by preventing degradation. However, due to its health risks, its use has been restricted or banned in certain countries.

Upstream product

• 1821-36-9 N-phenyl-2-cyclohexylamine 
• 110-46-3 isopentyl nitrite 

Downstream Products

• 1821-36-9 N-phenyl-2-cyclohexylamine 
• 77612-47-6 1-cyclohexyl-1-phenylhydrazine 
• 41657-77-6 N-cyclohexyl-4-nitroso-aniline 
• 173316-37-5 N-cyclohexyl-2-aminobenzonitrile 
• 93995-78-9 N-cyclohexyl-4-phenylazo-aniline 

Relevant academic research and scientific papers

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

Efficient procedure for chemoselective N-nitrosation of secondary amines with trichloromelamine-NaNO2

A combination of trichloromelamine and sodium nitrite in the presence of wet silica gel was used as an effective nitrosating agent for the transformation of secondary amines into the corresponding N-nitroso derivatives under mild and heterogeneous conditions in good to excellent yields.