5496-35-5

Basic information

• Product Name: 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID
• Synonyms: 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID;4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic Acid
• CAS NO: 5496-35-5
• Molecular Formula: C₂₂H₁₆N₂O₂
• Molecular Weight: 340.37
• Mol File: 5496-35-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 596.9 °C at 760 mmHg
• Flash Point: 314.8 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 4.3E-15mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.31±0.10(Predicted)
• CAS DataBase Reference: 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID(5496-35-5)
• EPA Substance Registry System: 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID(5496-35-5)

Safety Data

• Hazardous Substances Data: 5496-35-5(Hazardous Substances Data)

Usage

Uses

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic Acid is an anti-malarial agent with displayed ability to inhibit the activity of three metalloaminopeptidases. In addition, inhibits early stage of HIV-1 replication through disruption of the capsid protein.

InChI:InChI=1/C22H16N2O2/c25-22(26)18-13-11-17(12-14-18)21-23-19(15-7-3-1-4-8-15)20(24-21)16-9-5-2-6-10-16/h1-14H,(H,23,24)(H,25,26)

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 134-81-6 benzil 
• 623-27-8 terephthalaldehyde, 

Relevant articles and documents

IMIDAZOLE COMPOUND

PROBLEM TO BE SOLVED: To provide an imidazole compound which has: good solubility in raw materials when synthesizing a resin; and good reactivity in a dimerization-cleavage reaction in the resin. SOLUTION: The imidazole compound of the present invention i

Intramolecular charge transfer ampholytes with water-induced pendulum-type fluorescence variation

Triphenylimidazole-based ampholytes with intramolecular charge transfer were designed with the introduction of carboxyl groups. In solution, the synergistic solvent and ionization effects on the ampholytes led to a unique pendulum-type fluorescence variation during the water content increasing process. Among them, 4-(4,5-bis(4-hydroxyphenyl)-1H-imidazol-2-yl)benzoic acid showed the most prominent three-step fluorescence switching property.

Synthesis and characterization of nano-copper ferrite as a magnetically separable catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles under solvent-free condition

The authors report herein, synthesis and characterization of nano-copper ferrite as a recoverable, ecofriendly, inexpensive, and readily available catalyst for efficient, simple, and green synthesis of multisubstituted imidazoles. Short reaction times, high yields, easy workup, and mild condition are the advantages of this protocol. The catalyst can be reused without evident loss of the catalytic activity. Characterization of the catalyst was performed fully by Fourier transform infrared spectra, X-ray diffraction, FESEM, electron dispersive X-ray, and vibration sampling magnetometer analyses.