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Relevant academic research and scientific papers

Antimony trioxide as an efficient Lewis acid catalyst for the synthesis of 5-substituted 1H-tetrazoles

Sb2O3 was found to be effective as a catalyst for a smooth (2 + 3) cycloaddition of sodium azide with nitriles to afford 5-substituted 1H-tetrazoles in good yields. Copyright Taylor & Francis Group, LLC.

Practical scale up synthesis of carboxylic acids and their bioisosteres 5-substituted-1H-tetrazoles catalyzed by a graphene oxide-based solid acid carbocatalyst

Herein, catalytic application of a metal-free sulfonic acid functionalized reduced graphene oxide (SA-rGO) material is reported for the synthesis of both carboxylic acids and their bioisosteres, 5-substituted-1H-tetrazoles. SA-rGO as a catalytic material incorporates the intriguing properties of graphene oxide material with additional benefits of highly acidic sites due to sulfonic acid groups. The oxidation of aldehydes to carboxylic acids could be efficiently achieved using H2O2as a green oxidant with high TOF values (9.06-9.89 h?1). The 5-substituted-1H-tetrazoles could also be effectively synthesized with high TOF values (12.08-16.96 h?1). The synthesis of 5-substituted-1H-tetrazoles was corroborated by single crystal X-ray analysis and computational calculations of the proposed reaction mechanism which correlated well with experimental findings. Both of the reactions could be performed efficiently at gram scale (10 g) using the SA-rGO catalyst. SA-rGO displays eminent reusability up to eight runs without significant decrease in its productivity. Thus, these features make SA-rGO riveting from an industrial perspective.

Cadmium chloride as an efficient catalyst for neat synthesis of 5-substituted 1H-tetrazoles

Cadmium chloride (CdCl2) has been found to be an efficient catalyst for a neat [2+3]-cycloaddition of NaN3 with nitriles to afford 5-substituted 1H-tetrazoles in good yields. The shorter reaction times, greater yields of the product, and easy workup are the advantages of this methodology.

1,3-Dipolar cycloaddition: Click chemistry for the synthesis of 5-substituted tetrazoles from organoaluminum azides and nitriles

Cheap and safe: Conventional methods to prepare tetrazoles employ dangerous, toxic reagents. A new route to these heterocycles (see scheme) uses inexpensive and nontoxic dialkyl aluminum azides. The cycloaddition occurs under mild conditions and tolerates a variety of functional groups. The low cost and ecocompatibility make this process attractive for large-scale preparation. (Chemical Equation Presented).

Zinc hydroxyapatite - Catalyzed efficient synthesis of 5-substituted 1H-tetrazoles

Zinc hydroxyapatite (ZnHAP) is an effective heterogeneous catalyst for the (2 + 3)-cycloaddition of sodium azide with nitriles to afford 5-substituted 1H-tetrazoles in good yields. The catalyst is recovered and reused for several cycles with consistent ac

PROCESS FOR THE PREPARATION OF TETRAZOLE DERIVATIVES FROM ORGANO BORON AND ORGANO ALUMINIUM AZIDES

The present invention relates to a method for preparing substituted tetrazoles, compounds obtained according to this method, new reactants and new tetrazole derivatives.

A search for new glucophores by isosteric replacement of carboxylic function

We used arylsulfonylalkanoic acids as parent structures for designing new potential sweeteners. The Kohonen maps of the molecular electrostatic potential of the possible bioisosteric replacements of carboxylic function have been stimulated and used for th