54972-27-9Relevant academic research and scientific papers
Reductive aldol and mannich-type reactions of azetidin-3-ones promoted by titanium tetraiodide
Hata, Shingo,Fukuda, Daisuke,Hachiya, Iwao,Shimizu, Makoto
supporting information; experimental part, p. 473 - 477 (2010/08/23)
A convenient method is described for the generation and reaction of the enolates of aminoacetone equivalents, which uses the reduction of azetidin-3-one with titanium tetraiodide and subsequent reactions with electrophiles. This methodology provides a str
A general approach to polysubstituted pyrroles
Knight, David W.,Rost, Heinz C.,Sharland, Christopher M.,Singkhonrat, Jirada
, p. 7906 - 7910 (2008/03/27)
Exposure of a range of 3-hydroxy-2-sulfonylamino-4-alkynes to excess iodine delivers good yields of a series of iodopyrroles. Unexpectedly, the hydroxyl-dihydropyrroles, which were assumed to be the first-formed intermediates, turn out to be stable entities which have been isolated for the first time.
Titanium tetraiodide mediated reductive opening of aziridines, leading to the aldol and mannich-type reactions
Shimizu, Makoto,Kurokawa, Hiroshi,Nishiura, Shuji
, p. 57 - 64 (2007/10/03)
Reductive ring-opening of N-tosylazirindes was readily carried out with titanium tetraiodide to form the titanium enolates, which in turn were subjected to addition reaction with aldehydes or imines to give aldol or Mannich-type products in good yields.
