5498-83-9

Usage

Uses

Used in Bioconjugation:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a bioconjugation agent for the formation of stable covalent bonds between biomolecules and other molecules, such as drugs or imaging agents. The reactive amino group allows for easy attachment to target molecules, while the hydrophilic PEG spacer improves solubility and biocompatibility.
Used in Drug Delivery:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG spacer can enhance the circulation time of drugs in the body, while the reactive amino group allows for the attachment of drugs or other targeting moieties.
Used as a Crosslinker:
In the field of material science, 2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a crosslinker to connect and stabilize polymer chains, creating a network structure with enhanced mechanical properties and stability.
Used in PEG Hydrogel:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a building block in the formation of PEG hydrogels, which are versatile materials with applications in tissue engineering, drug delivery, and wound healing. The hydrophilic PEG spacer and reactive amino group contribute to the formation of a stable, hydrated network.
Used for Surface Functionalization:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used for surface functionalization to introduce specific chemical functionalities or biological moieties onto various surfaces, such as nanoparticles, microparticles, or planar substrates. This can enhance the performance of these materials in applications like sensors, catalysts, or targeted drug delivery systems.

InChI:InChI=1/C11H25NO5/c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3-2-12/h2-12H2,1H3

Upstream product

• 23778-52-1 3,6,9,12,15-pentaoxahexadecanol 
• 62921-74-8 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 
• 112-35-6 triethylene glucol monomethyl ether 
• 80755-67-5 3,6,9,12,15-pentaoxahexadecyl tosylate 
• 89485-61-0 16-azido-2,5,8,11,14-pentaoxahexadecane 

Downstream Products

• 92451-00-8 C₁₉H₃₂N₂O₁₀ 

Relevant academic research and scientific papers

Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors

CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.

Curcumin derivative and uses thereof

The present invention relates to a curcumin derivative represented by a general formula (I) or a pharmaceutically acceptable salt thereof, and a preparation method thereof, a composition containing aneffective amount of the compound represented by the general formula (I) or the pharmaceutically acceptable salt thereof, and applications of the compound represented by the general formula (I) or thepharmaceutically acceptable salt thereof in preparation of drugs for treatment of cancers, fatty liver, inflammations and the like, wherein R and R are defined in the specification.

ALKYNYL INDAZOLE DERIVATIVE AND USE THEREOF

The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like. The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof.

Lack of effect of the length of oligoglycine- and oligo(ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in solution

Using 1H NMR spectroscopy, values of T2 have been determined for the methylene protons of the oligoglycine moieties of para-substituted benzenesulfonamides having structures H2NO2SC6H4CO(Gly)(n)OH (n = 1-6) bound at the active site of bovine carbonic anhydrase II (CA, EC 4.2.1.1). These values have been correlated with measurements of dissociation constants of these complexes, in order to infer motion of these ligands when bound to the enzyme. Motion of glycines 1-3 (those closest to the aryl ring) is hindered by their proximity to the protein; motion of glycines 4-6 is relatively unhindered. Despite the restriction to motion inferred for glycines 1-3, the values of K(d) for the six compounds (n = 1-6, 1-6) are indistinguishable within experimental uncertainty (± 20%): K(d) in μM (n) 0.30 (1); 0.26 (2); 0.33 (3); 0.37 (4); 0.37 (5); 0.34 (6). There is, therefore, an unexpected compensation of the loss in conformational entropy on binding by another contributor to the free energy.