54981-01-0

Usage

Chemical structure

piperidine derivative with a benzyl group and an aminoethyl group attached to the piperidine ring

Biological activities

anti-inflammatory, analgesic, and neuroprotective properties

Potential pharmaceutical applications

treatment for neurological disorders and other therapeutic uses in the pharmaceutical industry

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 28544-30-1 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetonitrile 
• 28530-95-2 2-(1-benzyl-4-hydroxy-piperidin-4-yl)-acetamide 

Downstream Products

• 54981-06-5 9-benzyl-1-oxa-3,9-diaza-spiro[5.5]undecan-2-one 
• 909722-27-6 C₃₅H₃₉F₆N₃O₂ 
• 909722-26-5 C₃₅H₃₉F₆N₃O₂ 
• 903587-86-0 1,1-dimethylethyl-{2-[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]ethyl}carbamate 
• 54981-19-0 9-[4-(4-chloro-phenyl)-4-oxo-butyl]-1-oxa-3,9-diaza-spiro[5.5]undecan-2-one 
• 54981-15-6 9-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1-oxa-3,9-diaza-spiro[5.5]undecan-2-one 
• 54981-11-2 1-oxa-3,9-diaza-spiro[5.5]undecan-2-one 

Relevant academic research and scientific papers

N-[2-(1 -BENZYLPIPERIDIN-4-YL)ETHYL]-4-(PYRAZIN-2-YL)-PIPERAZINE-1 -CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC RECEPTOR 4 (M4) ANTAGONISTS FOR TREATING NEUROLOGICAL DISEASES

Provided herein are small molecule compounds of the following formula (I): or a stereoisomer, tautomer, solvate, ester or pharmaceutically acceptable salt thereof, wherein A, B, C, Li, L 2, Ri, R 2, R 3, R 4, R 5, w, x, y and z are as defined herein. Methods for treating diseases/ disorders by antagonizing muscarinic receptors, including specifically antagonizing muscarinic receptor 4 (M4), are also disclosed. Such diseases/disorders are e.g. neurological diseases/disorders such as e.g. Alzheimer's Disease, Lewy Body Dementia and the cognitive deficits associated with schizophrenia, Parkinson's Disease, drug induced Parkinsonism, dyskinesias, dystonia, chorea, levodopa induced dyskinesia, cerebral palsy, progressive supranuclear palsy, and Huntington's disease. Preferred compounds are e.g. N-[2-(l-benzylpiperidin-4-yl)ethyl]-4- (pyrazin-2-yl)-piperazine-1-carboxamide derivatives and related compounds wherein the pyrazine has been replaced by e.g. pyridazine, pyrimidine, pyridine or phenyl.

ANTIBACTERIAL AGENTS

Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Potential psychotropic drugs. X. Synthesis of butyrophenone derivatives with a piperidino spiro tetrahydrooxazinone structure having neuroleptic activity

New neuroleptic butyrophenone derivations, with a piperidino spirotetrahydrooxa zinone ring have been synthetised. These compounds have a neuroleptic profile analogous to that of haloperidol but their effective doses are higher. They are also less toxic t