54986-15-1

Usage

Type of compound

Tetrazole derivative

Usage

Synthesis of pharmaceuticals and agrochemicals

Potential applications

Medicinal chemistry, drug discovery

Biological activity

Exhibits activity against certain targets

Structure

Contains a tetrazole ring

Chemical properties

Interesting reactivity due to the tetrazole ring

Future implications

Further research and development may lead to new drugs and other useful applications

Upstream product

• 107575-07-5 5-(1-Methylethyl)-1,4-dimethyltetrazolium-perchlorat 
• 132126-17-1 5-(1-Methylethyl)-1,4-dimethyltetrazolium-trifluormethansulfonat 

Downstream Products

• 126822-13-7 4-Methyl-N-[1,4,6,6-tetramethyl-1,6-dihydro-4H-[1,2,3,4]tetrazin-(5Z)-ylidene]-benzenesulfonamide 
• 126822-20-6 C₁₃H₁₂⁽²⁾H₇N₅O₂S 
• 142362-62-7 1,4,9,9-Tetramethyl-6-(2-nitro-phenyl)-1,2,3,4,6,7,8-heptaaza-spiro[4.4]nona-2,7-diene 
• 142362-69-4 1,4,9,9-Tetramethyl-6-(4-nitro-phenyl)-1,2,3,4,6,7,8-heptaaza-spiro[4.4]nona-2,7-diene 
• 126822-13-7 4-Methyl-N-[1,4,6,6-tetramethyl-1,6-dihydro-4H-[1,2,3,4]tetrazin-(5Z)-ylidene]-benzenesulfonamide 
• 140111-29-1 Phenyl-[1,3,3-trimethyl-aziridin-(2E)-ylidene]-amine 
• 140111-30-4 Phenyl-[1,3,3-trimethyl-aziridin-(2Z)-ylidene]-amine 
• 88998-91-8 3,3-dimethyl-2-methylimino-1-phenylaziridine 
• 88998-95-2 [3,3-Dimethyl-1-phenyl-aziridin-(2Z)-ylidene]-methyl-amine 
• 593-75-9 methyl isocyanate 
• 6407-34-7 methyl-1 ethylideneamine 
• 126134-30-3 7-Isopropyl-1,4,6,10,10-pentamethyl-1,2,3,4,6,8-hexaazaspiro<4,5>deca-2,7-dien 
• 54986-26-4 (E)-N-(1,3,3-Trimethyl-2-aziridinyliden)methanamin 
• 54986-25-3 (Z)-N-(1,3,3-Trimethyl-2-aziridinyliden)methanamin 

Relevant academic research and scientific papers

Cycloaddition of Methyl Azide to 5-Alkylidene-1,4-dihydro-1,4-dimethyl-5H-tetrazoles

Sodium hydride deprotonates the 5-alkyl-1,4-dimethyltetrazolium ions 4 affording the air-sensitive, yellow, distillable 5-alkylidene-1,4-dihydro-5H-tetrazoles 1.In addition, small amounts of the spiro compound 5a are formed through cleavage of 4a by nucleophiles yielding methyl azide followed by cycloaddition of the latter to give 1a.In separate experiments, methyl azide reacts smoothly with 1 at temperatures as low as 0-20 deg C producing the spiro compounds 5 which exhibit suprising thermal stability.The structures of the cycloadducts 5 are based on spectra and the base-induced cleavage of 5b into methyl azide and aminotriazole 16.The latter is synthesized independently from tert-butylacetonitrile and methyl azide.