54997-33-0

Upstream product

• 54997-29-4 2-(4-Isopropylphenylthio)phenylacetonitril 
• 4946-14-9 4-mercapto-cumene 
• 18698-96-9 o-iodophenylacetic acid 
• 54997-24-9 C₁₆H₁₇ClS 
• 54997-21-6 2-(4-Isopropylphenylthio)benzylalkohol 
• 5495-75-0 2-(4-isopropylphenylthio)benzoic acid 

Relevant academic research and scientific papers

DIHYDROBENZO[B][1]BENZOTHIEPIN COMPOUNDS USEFUL IN THERAPY

The present invention relates to the use of a compound of formula (I), to decrease or inhibit, in vitro or ex vivo, the Patched receptor drug efflux activity, in particular the chemotherapeutic drug efflux activity and chemotherapy resistance. The present disclosure further relates to uses of such compounds, in particular to prepare a pharmaceutical composition to allow or improve the efficiency of a therapy of cancer in a subject in need thereof. The compound of the invention can indeed be advantageously used, in combination with at least one chemotherapeutic drug, for treating cancer, for preventing cancer metastasis and/or for preventing cancer recurrence in a subject.