54997-99-8

Basic information

• Product Name: 2-NITRO-5-PIPERIDINOANILINE
• Synonyms: 2-NITRO-5-PIPERIDINOANILINE
• CAS NO: 54997-99-8
• Molecular Formula: C₁₁H₁₅N₃O₂
• Molecular Weight: 221.26
• Mol File: 54997-99-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 102-104°
• Boiling Point: 441.8 °C at 760 mmHg
• Flash Point: 221 °C
• Appearance: /
• Density: 1.258g/cm³
• Vapor Pressure: 5.29E-08mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 2-NITRO-5-PIPERIDINOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-5-PIPERIDINOANILINE(54997-99-8)
• EPA Substance Registry System: 2-NITRO-5-PIPERIDINOANILINE(54997-99-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 54997-99-8(Hazardous Substances Data)

Usage

General Description

2-NITRO-5-PIPERIDINOANILINE is a chemical compound that is also known by the name Nifurfoline. It is a nitrofuran derivative that is commonly used as a antimicrobial and antiprotozoal agent. It has been used in veterinary medicine for the treatment of infections in farm animals, and it has also shown potential as a treatment for leishmaniasis, a parasitic disease caused by protozoa of the genus Leishmania. However, it has also been associated with potential mutagenic and carcinogenic properties, and its use in human medicine has been restricted in some countries. Overall, 2-NITRO-5-PIPERIDINOANILINE is a potent chemical with both therapeutic potential and potential health risks.

InChI:InChI=1/C11H15N3O2/c12-10-8-9(4-5-11(10)14(15)16)13-6-2-1-3-7-13/h4-5,8H,1-3,6-7,12H2

Upstream product

• 110-89-4 piperidine 
• 1635-61-6 5-chloro-2-nitroaniline 
• 2369-11-1 5-fluoro-2-nitroaniline 

Downstream Products

• 897446-63-8 2-cyclohexyl-N-(2-nitro-5-piperidin-1-ylphenyl)-2-phenylacetamide 
• 54998-07-1 4-<5'-(piperidin-1''-yl)-1H-benzimidazol-2'-yl>-2-nitroaniline 
• 54998-26-4 2-amino-4-<5'-(piperidin-1''-yl)benzimidazol-2'-yl>aniline 
• 155198-10-0 2-amino-4-(piperidin-1'-yl)aniline 

Relevant articles and documents

Benzimidazole compound, preparation method thereof and application of the benzimidazole compound in preparation of ferroptosis inhibitor

The invention discloses a benzimidazole compound, a preparation method thereof and application of the benzimidazole compound in preparation of a ferroptosis inhibitor. The benzimidazole compound has a structure as shown in a formula (I) or a formula (II)

Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation

Fibroblast growth factor receptor (FGFR) represents an attractive oncology target for cancer therapy in view of its critical role in promoting cancer formation and progression, as well as causing resistance to approved therapies. In this article, we describe the identification of the potent pan-FGFR inhibitor (R)-21c (FGFR1-4 IC50 values of 0.9, 2.0, 2.0, and 6.1 nM, respectively). Compound (R)-21c exhibited excellent in vitro inhibitory activity against a panel of FGFR-amplified cell lines. Western blot analysis demonstrated that (R)-21c suppressed FGF/FGFR and downstream signaling pathways at nanomolar concentrations. Moreover, (R)-21c provided nearly complete inhibition of tumor growth (96.9% TGI) in NCI-H1581 (FGFR1-amplified) xenograft mice model at the dose of 10 mg/kg/qd via oral administration.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.