55-27-6

Usage

Uses

Used in Pharmaceutical and Medical Research:
DL-NORADRENALINE HYDROCHLORIDE is used as a research compound for investigating the effects of adrenergic drugs on the lantern of larval fly. This application helps in understanding the role of adrenergic drugs in biological systems and their potential impact on various organisms.
Used in Cardiology Studies:
In the field of cardiology, DL-NORADRENALINE HYDROCHLORIDE is used as a pharmacological tool to evaluate the ability of α-adrenergic stimulation in the presence of elevated calcium levels to induce delayed after depolarizations and triggered activity in Purkinje fibers isolated from cat hearts. This application aids in understanding the mechanisms of cardiac arrhythmias and the potential therapeutic interventions.
Used in Material Science and Nanotechnology:
DL-NORADRENALINE HYDROCHLORIDE is used as a reducing and surface functionalization agent in the simultaneous reduction and surface functionalization of graphene oxide through a one-step poly(norepinephrine) functionalization process. This application is crucial in the development of advanced materials with tailored properties for various applications, including energy storage, sensors, and electronics.

Safety Profile

Poison by intraperitoneal andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic fumes ofNOx and HCl.

InChI:InChI=1/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1/t8-/m0/s1

Upstream product

• 1207201-66-8 tert-butyl 2-(3,4-dihydroxyphenyl)-2-hydroxyethylcarbamate 
• 5090-29-9 1-(3,4-dihydroxyphenyl)-1-oxo-2-amino-ethan-hydrochlorid 

Downstream Products

• 88719-61-3 {5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-carbamic acid benzyl ester; hydrochloride 
• 88719-46-4 N-{3-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-butyl}-4-methyl-benzamide; hydrochloride 
• 95483-99-1 N-{4-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-pentyl}-2-methyl-benzamide; hydrochloride 
• 88719-47-5 N-{4-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-pentyl}-4-methyl-benzamide; hydrochloride 
• 88719-60-2 N-{5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-2-methyl-benzamide; hydrochloride 
• 88719-48-6 N-{5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-4-methyl-benzamide; hydrochloride 
• 88719-49-7 N-{6-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-heptyl}-4-methyl-benzamide; hydrochloride 
• 41462-32-2 1,2,3,4-tetrahydro-4,6,7-isoquinolinetriol hydrochloride 
• 88719-36-2 4-[2-(4-Amino-1-methyl-butylamino)-1-hydroxy-ethyl]-benzene-1,2-diol; hydrochloride 
• 88719-35-1 4-[2-(3-Amino-1-methyl-propylamino)-1-hydroxy-ethyl]-benzene-1,2-diol; hydrochloride 
• 24159-36-2 dopamine β-sulfonate 
• 95484-08-5 C₂₉H₄₂N₆O₇*ClH 
• 95483-85-5 {6-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-heptyl}-carbamic acid benzyl ester; hydrochloride 
• 95483-02-6 (4-Methyl-benzoyl)-carbamic acid 4-[2-(3,4-dihydroxy-phenyl)-2-hydroxy-ethylamino]-pentyl ester 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF (DL) -NOREPINEPHRINE ACID ADDITION SALT, A KEY INTERMEDIATE OF (R) - (-) - NOREPINEPHRINE

The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also discloses a novel intermediate formed in the process and its synthesis.

A new and efficient route for the synthesis of naturally occurring catecholamines

Catecholamines, sympathomimetic drugs and adrenergic receptor antagonists, have been prepared by a regioselective oxidation of the corresponding 4-hydroxyphenethylamine derivatives by 2-iodoxybenzoic acid (IBX) in homogeneous as well as in heterogeneous conditions and followed by cleavage of the amino protective group. By using polymer-supported IBX, after the first oxidation, the oxidant can be recovered, regenerated, and efficiently reused for several additional times. An efficient, easy and green procedure for the synthesis of N-(methoxycarbonyl)dopamine, key component of many pharmaceuticals, has also been reported. Georg Thieme Verlag Stuttgart.