55000-02-7Relevant academic research and scientific papers
Identification of small molecules that inhibit GSK-3β through virtual screening
Kang, Nam Sook,Lee, Gil Nam,Kim, Chi Hyun,Bae, Myung Ae,Kim, Ikyon,Cho, Young Sik
scheme or table, p. 533 - 537 (2011/03/20)
Glycogen synthase kinase-3β (GSK-3β) is involved in glycogen metabolism, neuronal cell development, osteoblast differentiation. Small molecule inhibitors of GSK-3β have various therapeutic potential for the treatment of diabetes type II, bipolar disorders
Enzyme inhibitors
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Page/Page column 5-6, (2010/01/31)
Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is involved, including Alzheimer's disea
First non-ATP competitive glycogen synthase kinase 3 β (GSK-3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease
Martinez, Ana,Alonso, Mercedes,Castro, Ana,Pérez, Concepción,Moreno, Francisco J.
, p. 1292 - 1299 (2007/10/03)
Glycogen synthase kinase 3 β (GSK-3β) has a central role in Alzheimer′s disease (AD). Selective inhibitors which avoid τ hyperphosphorylation may represent an effective therapeutical approach to the AD pharmacotherapy and other neurodegenerative disorders
N-benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors
Martinez, Ana,Fernandez, Enrique,Castro, Ana,Conde, Santiago,Rodriguez-Franco, Isabel,Baos, Josep-Eladi,Badia, Albert
, p. 913 - 922 (2007/10/03)
A new family of 1,2,4-thiadiazolidinone derivatives containing the N-benzylpiperidine fragment has been synthesised. The acetylcholinesterase (AChE) inhibitory activity of all compounds was measured using Ellman's method and some of them turned out to be as potent as tacrine. Furthermore, compound 13 was as active as tacrine in reversing the blockade induced by tubocurarine at rat neuromuscular junction. Additionally, receptor binding studies provided new lead compounds for further development of α2-adrenergic and sigma-receptor antagonists. Molecular dynamic simulation using X-ray crystal, structure of AChE from Torpedo californica was used to explain the possible binding mode of these new compounds. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
