55004-35-8Relevant academic research and scientific papers
Enantioselective vinylogous aldol reaction of acylphosphonates with 3-alkylidene oxindoles
Jaiswal, Manish K.,Singh, Ravi P.,Singh, Sanjay
supporting information, p. 7861 - 7866 (2021/09/28)
A simple strategy for yielding chiral tertiary α-hydroxy phosphonates that integrates two highly biologically relevant scaffolds namely 3-alkylidene-2-oxindoles and phosphonates has been described. The hydrogen bonding ability of the bifunctional thiourea catalyst allows simultaneous dual activation of a vinylogous oxindole nucleophile and an acylphosphonate electrophile, affording hydroxyphosphonato-3-alkylidene-2-oxindoles as aldol adducts in high yields (up to 92%) with excellent stereocontrol (up to 99% ee).
Catalytic Aldol-Cyclization Cascade of 3-Isothiocyanato Oxindoles with α-Ketophosphonates for the Enantioselective Synthesis of β-Amino-α-hydroxyphosphonates
Kayal, Satavisha,Mukherjee, Santanu
supporting information, p. 5508 - 5511 (2015/11/18)
A cascade aldol-cyclization reaction between 3-isothiocyanato oxindoles and α-ketophosphonates has been developed for the synthesis of β-amino-α-hydroxyphosphonate derivatives. Catalyzed by a quinine-based tertiary amino-thiourea derivative, this reaction
Asymmetric homoenolate additions to acyl phosphonates through rational design of a tailored N-heterocyclic carbene catalyst
Jang, Ki Po,Hutson, Gerri E.,Johnston, Ryne C.,McCusker, Elizabeth O.,Cheong, Paul H.-Y.,Scheidt, Karl A.
supporting information, p. 76 - 79 (2014/01/23)
A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enanti
Sigmatropic Isomerizations in 2-Azaallyl Systems. XVI. Electronic Effects of Phosphorylated Azaallyl Group
Onys'ko,Kim,Kiseleva,Prokopenko,Sinitsa
, p. 701 - 705 (2007/10/03)
Meta- and para-fluorobenzenes XC6H4F containing a mono- and diphosphorylated 2-azaallyl group [X = PhCH2N=C[P(O)(OEt)2], (EtO)2P(O)CH2N=CH, Ph2P(O)CHPhN=CH, (EtO)2P(O)
