550299-69-9

Upstream product

• 996-98-5 oxalic acid hydrazide 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Relevant academic research and scientific papers

Ligational, analytical and biological applications on oxalyl bis(3,4-dihydroxybenzylidene) hydrazone

The molecular modeling and parameters have been calculated to confirm the geometry of oxalyl bis(3,4-dihydroxybenzylidene) hydrazone, H6L. The metal complexes of Cr3+, VO2+, ZrO2+, HfO 2+, UO22+ and MoO22+ with H6L have been prepared and characterized by partial elemental analysis, spectral studies (electronic; IR), thermal analysis and magnetic measurements. The data suggest the formation of polymer complexes with a unit [Cr(H4L)(H2O)3Cl]·H2O, [VO(H4L)(H2O)2], [Hf(H4L)(H 2O)]·H2O [UO2(H4L)(H 2O)2]·2H2O [MoO2(H 4L)] and [(ZrO)2(H2L)-(C2H 5OH)2]. The ligand behaves as a dibasic bidentate in all complexes except ZrO2+ which acts as a tetrabasic tetradentate with the two ZrO2+ ions. An octahedral geometry was proposed for the Cr3+, HfO2+, MoO22+and UO 22+ complexes and square pyramid for VO2+. The Cr3+ is necessary to degrade the DNA of eukaryotic subject completely; the other complexes have little effect. H6L was found suitable as a new reagent for the separation and preconcentration of ZrO 2+ ions from different water samples using flotation technique with satisfactory results.

Acetyl hydrazone derivative, and preparation method and application thereof

The invention relates to an acetyl hydrazone derivative shown in a chemical structural formula I, a pharmaceutically acceptable salt of the acetyl hydrazone derivative, a pharmaceutical composition and an application of the acetyl hydrazone derivative and the pharmaceutically acceptable salt in preparation of influenza-virus neuraminidase inhibitors. In the structural formula I, R is selected fromhydroxyl, dihydroxyl, 2-hydroxy-3-methoxy, 2-hydroxy-4-methoxy, 2-hydroxy-5-methoxy, 2-hydroxy-6-methoxy, 3-hydroxy-2-methoxy, 3-hydroxy-4-methoxy, 3-hydroxy-5-methoxy, 3-hydroxy-6-methoxy, 4-hydroxy-2-methoxy, 4-hydroxy-3-methoxy, 4-hydroxy-3,5-dimethoxy, 2-hydroxy-3-ethoxy, 2-hydroxy-4-ethoxy, 2-hydroxy-5-ethoxy, 2-hydroxy-6-ethoxy, 3-hydroxy-2-ethoxy, 3-hydroxy-4-ethoxy, 3-hydroxy-5-ethoxy, 3-hydroxy-6-ethoxy, 4-hydroxy-2-ethoxy, 4-hydroxy-3-ethoxy, 4-hydroxy-3,5-diethoxy, trihydroxy or 4-hydroxy-3,5-dimethyl.

Polyphenol compounds

PROBLEM TO BE SOLVED: To provide a polyphenol compound which has an inhibitory activity for poly(ADP-ribose)glycohydrase (PARG) and is useful as an anticancer agent or the like.SOLUTION: There is provided a polyphenol compound represented by the formula (I) or a pharmaceutically acceptable salt thereof (where, X represents a mono to tri-valent aromatic hydrocarbon group or aromatic heterocyclic group or the like; Y represents -N(R)-, -NHCO- or a bond; Rand Rrepresent a hydrogen atom, an alkyl group or the like; n represents 1, 2 or 3; and m represents an integer of 2 to 5.)