55037-87-1

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-[(4-chlorophenyl)methyl]-, ethyl ester
• CAS NO: 55037-87-1
• Molecular Formula: C14H19ClN2O2
• Molecular Weight: 282.77
• Mol File: 55037-87-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-[(4-chlorophenyl)methyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-[(4-chlorophenyl)methyl]-, ethyl ester(55037-87-1)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-[(4-chlorophenyl)methyl]-, ethyl ester(55037-87-1)

Safety Data

• Hazardous Substances Data: 55037-87-1(Hazardous Substances Data)

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 104-88-1 4-chlorobenzaldehyde 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 91860-37-6 2-<4-(4-chlorobenzyl)piperazin-1-yl>ethanol 
• 75590-45-3 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-8-n-propylcoumarin-7-yloxy)propyl]piperazine 
• 91860-38-7 1-(4-chlorobenzyl)-4-<2-<(4-ethoxycoumarin-7-yl)oxy>ethyl>piperazine 
• 75590-64-6 1-(4-chlorobenzyl)-4-<(4-ethoxycoumarin-7-yl)methyl>piperazine 
• 75590-38-4 7-{3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-propoxy}-4-hydroxy-3-nitro-chromen-2-one; compound with nitric acid 
• 75590-50-0 7-{2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-ethoxy}-4-hydroxy-chromen-2-one; hydrochloride 
• 75590-56-6 7-[4-(4-Chloro-benzyl)-piperazin-1-ylmethyl]-4-hydroxy-chromen-2-one; hydrochloride 
• 75590-44-2 1-<3-<<8-allyl-4-(benzyloxy)coumarin-7-yl>oxy>-2-hydroxypropyl>-4-(4-chlorobenzyl)piperazine 
• 75590-46-4 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine 
• 75590-40-8 1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>-2-hydroxypropyl>-4-(4-chlorobenzyl)piperazine 
• 75590-35-1 1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine 
• 75590-42-0 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitrocoumarin-7-yloxy)propyl]piperazine 
• 75590-51-1 1-(4-chlorobenzyl)-4-[2-(4-hydroxy-3-nitrocoumarin-7-yloxy)ethyl]piperazine 
• 75590-41-9 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine 

Relevant articles and documents

Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships

A series of 28 flavonoid derivatives containing a N-benzylpiperazine chain have been synthesized and tested for their ability to modulate multidrug resistance (MDR) in vitro. At 5 μM, most compounds potentiated doxorubicin cytotoxicity on resistant K562/DOX cells. They were also able to increase the intracellular accumulation of JC-1, a fluorescent molecule recently described as a probe of P-glycoprotein-mediated MDR. This suggests that these compounds act, at least in part, by inhibiting P-glycoprotein activity. As in other studies, lipophilicity was shown to influence MDR- modulating activity but was not the only determinant. Diverse di- and trimethoxy substitutions on N-benzyl were examined and found to affect the activity differently. The most active compounds had a 2,3,4- trimethoxybenzylpiperazine chain attached to either a flavone or a flavanone moiety (13, 19, 33, and 37) and were found to be more potent than verapamil.