55039-67-3

Basic information

• Product Name: 4-(2,3-dichlorophenyl)morpholine
• Synonyms: 4-(2,3-dichlorophenyl)morpholine
• CAS NO: 55039-67-3
• Molecular Weight: 232.109
• Mol File: 55039-67-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,3-dichlorophenyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,3-dichlorophenyl)morpholine(55039-67-3)
• EPA Substance Registry System: 4-(2,3-dichlorophenyl)morpholine(55039-67-3)

Safety Data

• Hazardous Substances Data: 55039-67-3(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 120-82-1 1,2,4-Trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 23328-69-0 4-chloromorpholine 
• 1449472-59-6 2-chloro-6-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 55048-21-0 2-chloro-N,N-diisopropyl-3-morpholin-4-yl-aniline 
• 55048-27-6 tetra-N-isopropyl-4-morpholin-4-yl-benzene-1,3-diamine 
• 55048-38-9 3-chloro-N,N-diisopropyl-4-morpholin-4-yl-aniline 

Relevant articles and documents

Synthesis of ortho -haloaminoarenes by aryne insertion of nitrogen-halide Bonds

A rapid and general access to ortho-haloaminoarenes has been developed by aryne insertion into N-chloramine, N-bromoamine, and N-iodoamine bonds via two complementary protocols harnessing fluoride-promoted 1,2-elimination of ortho-trimethylsilyl aryltriflates. Typically, electron-deficient N-chloramines effectively react with aryne intermediates generated at elevated temperature with CsF, while less stable N-haloamines are found more efficient under milder, TBAF-mediated aryne formation at room temperature. Both protocols demonstrate a good level of regioselectivity and functional group tolerance. Efforts to elucidate the mechanism of N-X insertion are also discussed. The practical value of this transformation is highlighted by rapid synthesis of novel analogues of the antipsychotic cariprazine.