55047-37-5

Basic information

• Product Name: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one
• Synonyms: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one;3-hydroxy-4-methyl-7,8,9,10-tetrahydrobenzo[c]chromen-6-one;ChemDiv1_023555;EU-0074151;MLS000061951;Oprea1_706360;SMR000070812;ST5447665
• CAS NO: 55047-37-5
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.25916
• Mol File: 55047-37-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one(55047-37-5)
• EPA Substance Registry System: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one(55047-37-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 55047-37-5(Hazardous Substances Data)

Upstream product

• 608-25-3 2-methylbenzene-1,3-diol 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 374757-36-5 3-[2-(1,3-benzodioxol-5-yl)-2-oxoethoxy]-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one 
• 307550-04-5 4-methyl-3-(1-methyl-2-oxopropoxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one 
• 374762-87-5 3-[2-(4-methoxyphenyl)-2-oxoethoxy]-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one 
• 307549-97-9 tert-butyl {(4-methyl-6-oxo-7,8,9,10-tetrahydro-6H-benzo[c]chromen-3-yl)oxy}acetate 
• 86557-19-9 <(2-Benzoyl-7,8,9,10-tetrahydro-4-methyl-6-oxo-6H-dibenzopyran-3-yl)oxy>acetic acid ethyl ester 
• 86557-21-3 <(2-Benzoyl-7,8,9,10-tetrahydro-4-methyl-6-oxo-6H-dibenzopyran-3-yl)oxy>acetic acid 
• 86557-17-7 2-Benzoyl-3-hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one 
• 86557-18-8 2-Acetyl-3-hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one 
• 374710-33-5 10-(4-fluorophenyl)-7-methyl-1,2,3,4-tetrahydro-5H-benzo[c]furo[3,2-g]chromen-5-one 
• 374708-26-6 10-(4-chlorophenyl)-7-methyl-1,2,3,4-tetrahydro-5H-benzo[c]furo[3,2-g]chromen-5-one 
• 433700-22-2 10-(3-methoxyphenyl)-7-methyl-1,2,3,4-tetrahydro-5H-benzo[c]furo[3,2-g]chromen-5-one 
• 370585-26-5 10-(4-methoxyphenyl)-7-methyl-1,2,3,4-tetrahydro-5H-benzo[c]furo[3,2-g]chromen-5-one 
• 444996-47-8 10-(4-bromophenyl)-7-methyl-1,2,3,4-tetrahydro-5H-benzo[c]furo[3,2-g]chromen-5-one 
• 370584-49-9 7-methyl-10-(4-methylphenyl)-1,2,3,4-tetrahydro-5H-benzo[c]furo[3,2-g]chromen-5-one 

Relevant articles and documents

Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors

For the early diagnosis of cancer, leading to a better chance of full recovery, marker genes whose expression is already altered in precancerous lesions are desirable, and the tumor-suppressor gene FHIT is one candidate. The gene product, FHIT protein, has a unique dinucleoside triphosphate hydrolase (AP3Aase) activity, and in this study, we designed and synthesized a series of FHIT fluorescent probes utilizing this activity. We optimized the probe structure for high and specific reactivity with FHIT and applied the optimized probe in a screening assay for FHIT inhibitors. Screening of a compound library with this assay identified several hits. Structural development of a hit compound afforded potent FHIT inhibitors. These inhibitors induce apoptosis in FHIT-expressing cancers via caspase activation. Our results support the idea that FHIT binders, no matter whether inhibitors or agonists of AP3Aase activity, might be promising anticancer agents.

Modified coumarins. 7. Synthesis and biological activity of mannich bases of substituted 7,8,9,10-tetrahydrobenzo[c]chromen-6-ones

Condensation of 1- and 3-hydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-ones with substituted 1,1-diaminomethanes produced Mannich bases containing a dialkylaminomethyl group in the 2- and 4-positions of 7, 8,9,10-tetrahydrobenzo[c]chromen-6-one. Pharmacological screening of 2-chloro-3-hydroxy-4-(1-pyrrolidinylmethyl)-7,8,9,10-tetrahydro-6H-benzo[c] chromen-6-one in Wistar rats showed that it possesses low toxicity and acts as a stimulant of the central and peripheral nervous systems with indications of neuroleptic and tranquilizing activities.