5509-90-0Relevant academic research and scientific papers
Preparation of 1,5-disubstituted tetrazoles under phase-transfer conditions
Artamonova,Zhivich,Dubinskii,Koldobskii
, p. 1428 - 1430 (2007/10/03)
Imidoyl chlorides, obtained by common methods from a wide range of aromatic mono- and diamides, are smoothly converted to the corresponding tetrazoles in high yields by treatment with NaN3 under phase-transfer conditions.
Syntheses and basicity of 4-(N,N-dimethylamino)-2-arylquinazolines
Zielinski, Wojciech,Kudelko, Agnieszka,Holt, Elizabeth M.
, p. 1201 - 1209 (2007/10/03)
The reaction of substituted N-phenylbenzimidoyl chlorides with N,N-dimethylcyanamide in the presence of titanium tetrachloride has yielded seven 4-(N,N-dimethylamino)-2-arylquinazolines substituted on the phenyl ring with electron donating or withdrawing groups. pKa values have been determined for these compounds and analyzed in conjunction with the Hammertt σ constants to observe the influence of these phenyl substituents upon the basicity of 4-(N,N-dimemylamino)-2-arylquinazolines. The σ value, single crystal X-ray analysis and 15N-nmr spectra give evidence about the preferential site of protonation in such systems.
