55090-32-9

Upstream product

• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 
• 108-86-1 bromobenzene 
• 591-51-5 phenyllithium 

Downstream Products

• 19104-19-9 5-Phenyl-10,11-dihydro-5H-dibenzocyclohepten 
• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 

Relevant academic research and scientific papers

Functionalized triarylcarbenium ions as catalysts in mukaiyama aldol addition: Effects of counter ions and silyl groups on the intervention of silyl catalysis

Stereochemical studies have indicated that functionalized Tr+SbCl6- may serve as efficient aldol reaction catalysts by judicious choice of a silyl component. The aldol addition between TMS ketene acetal derived from γ-butyrolactone and benzaldehyde provided the silyl aldolates with high syn diastereoselectivities.

Structure-guided design of novel l -Cysteine derivatives as potent KSP inhibitors

Kinesin spindle protein (KSP), known as Hs Eg5, a member of the kinesin-5 family, plays an important role in the formation and maintenance of the bipolar spindle. We previously reported S-trityl-l-cysteine derivatives as selective KSP inhibitors. Here, we report further optimizations using docking modeling in the L5 allosteric binding site, which led to the discovery of several high affinity derivatives with two fused phenyl rings in the trityl group giving low nanomolar range KSP ATPase inhibition. The representative derivatives potently inhibited cell growth of HCT116 cells in correlation with KSP inhibitory activities and significantly suppressed tumor growth in the xenograft model in vivo.

New and its salt cysteines compd.

The purpose of the present invention is to provide a novel compound with Eg5 inhibiting activity that is useful as an antitumoral agent. The present invention pertains to a compound expressed by the general formula (I) (in formula (I), A represents Ch2, a

Investigation of the solvent enclathration potentials of 5-phenyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol and related seven-membered ring alcohols

Four previously reported tricyclic alcohols containing seven-membered central B-rings, 5-phenyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol, 5-phenyl-5H-dibenzo[a,d]cyclohepten-5-ol, 11-phenyl-6,11-dihydrodibenzo[b,e] oxepin-11-ol and 11-phenyl-6,11-dihydrodibenzo[b,e]thiepin-11-ol have been synthesized and their solvent enclathration (inclusion) properties investigated and compared by using 1H-NMR and differential scanning calorimetry (DSC). The presence of an oxygen or a sulphur atom, respectively, in the B-ring of the latter two compounds had a detrimental effect on the solvent enclathration properties of the host compounds as compared to those containing an ethane or ethylene bridge. This suggests that, although enclathration is highly dependent on the hydrogen bonding ability of the host, rigidity of the structure plays a crucial role in the formation and stability of these complexes.

Tricylic amino-acid derivatives

Described herein are compounds which have the general formula: or a prodrug or pharmaceutically acceptable salt, solvate or hydrate thereof wherein: R1 is selected from the group consisting of H, alkyl and the counter ion for a basic addition salt; X is selected from the group consisting of CR9R10, S, O, SO, SO2, NH and N-alkyl; R2, R3, R4, R9 and R10 are independently selected from the group consisting of H and alkyl; R5 and R6 are independently selected from the group consisting of H, alkyl and phenyl, or, alternatively, R5 and R6 together may form a methylene group or a 3- to 6-membered a spirocyclic group; wherein, when X is CR9R10, one or both pairs of R5 and R9 or R6 and R10 may join to form a double or triple bond R7 is selected from the group consisting of Formula II-V: which are all optionally substituted, at nodes other than R8, with 1-4 substituents independently selected from the group consisting of alkyl, halo, aryl (which may be substituted as for R8), trifluoromethyl, trifluoromethoxy, nitro, cyano, amino, mono-alkylamino, di-alkylamino, alkoxycarbonyl, alkylcarbonyl, alkoxythiocarbonyl, alkylthiocarbonyl, alkoxy, alkylS-, phenoxy, -SO2NH2, -SO2NHalkyl, -SO2N(alkyl)2 and 1,2-methylenedioxy; and wherein any of the benzo-fused rings in structures II to V may be replaced by a 5- or 6-membered heterocyclic ring selected from the group consisting of pyridine, thiophene, furan and pyrrole; wherein R8 is selected from the group consisting of H, alkyl, benzyl, cycloalkyl, indanyl and an optionally substituted aryl group, wherein the optional substituents are independently selected from 1-4 members of the group consisting of alkyl, halo, aryl, trifluoromethyl, trifluoromethoxy, nitro, cyano, amino, mono-alkylamino, di-alkylamino, alkoxycarbonyl, alkylcarbonyl, alkoxythiocarbonyl, alkylthiocarbonyl, alkoxy, alkylS-, phenoxy, -SO2NH2, -SO2NHalkyl, -SO2N(alkyl)2 and 1,2-methylenedioxy; -represents a single or double bond; Y is selected from the group consisting of O, S, SO, NH, N-alkyl, CH2, CH-alkyl, C(alkyl)2, and C=O; Z is selected from the group consisting of CH2, O, S, NH and N-alkyl when-is a single bond; Z is selected from the group consisting of CH and N when-is a double bond. Also described is the use of these compounds as pharmaceuticals.

Versatile and Convenient Lattice Hosts derived from Singly Bridged Triarylmethane Frameworks, X-Ray Crystal Structures of Three Inclusion Compounds

A new family of host molecules, based on the singly bridged triarylmethanol and triarylacetic acid frameworks, is described.These hosts form crystalline inclusions with a variety of uncharged organic molecules ranging from protic dipolar to apolar compounds (130 different species).The formation and stoicheiometry depend in a systematic manner on structural parameters of the host, such as the nature of the functional group and the substituents, and on the substituent positions.The crystal structures of three inclusion compounds have been studied by X-ray diffraction.They reveal the building principles of the new inclusion family.In the crystals of 1a*benzene (8:3), the benzene is interstitially entrapped by H-bonded tetramer clusters of 1a.Crystals of 1a*dioxane (4:3) are built of H-bonded 2:1 host-guest complexes including interstitial molecules of dioxane.In the case of 4c*EtOH (1:1), the building principle is formation of 2:2 host-guest clusters via a twelve-membered H-bonded ring.

Synthesis of o-Substituted Phenols by Criegee Rearrangement of Benzylic Hydroperoxides

9-Phenylthioxanthen-9-ol, 10,10-dimethyl-9-phenyl-9,10-dihydroanthracen-9-ol, and 9-arylfluoren-9-ols undergo Criegee-type rearrangements when treated with hydrogen peroxide and acid to generate substituted benzophenones from the first two substrates, and monoesters of biphenyl-2,2'-diol from the fluorenes via subsequent Bayer-Villiger oxidation of the intermediate 2'-aroylbiphenyl-2-ol. 5-Phenyl-10,11-dihydrodibenzocyclohepten-5-ol and its dehydroderivative gave the corresponding heptanone and heptenone on treatment with acid and hydrogen peroxide.Prolonged reaction of the 5-phenyldibenzohepten-5-ol afforded products arising from oxidation of the double bond.