55094-77-4

Upstream product

• 458-37-7 curcumin 
• 74-88-4 methyl iodide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 123-54-6 acetylacetone 
• 186581-53-3 diazomethane 
• 458-37-7 curcumin 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids

A variety of novel aromatic and heterocyclic aromatic curcuminoids were synthesised, characterised and their anti-inflammatory activities (AIA) determined in vivo. Some of these compounds also were tested for inflammatory mediator production. The AIA of t

Synthesis, characterization and ROS-mediated antitumor effects of palladium(II) complexes of curcuminoids

Based on the synthesis of curcumin and its derivatives from aromatic aldehydes, a novel series of palladium(II) complexes with curcumin (or its derivatives) and 2,2′-bipyridine have been synthesized through a directed self-assembly approach that involves spontaneous deprotonation of the curcuminoid ligands in H2O/acetone solution. These complexes have been characterized by 1H (13C) NMR, HRMS and elemental analysis. Crystal structure of 3h has been determined by X-ray diffraction analysis. Their cytotoxicity was tested by MTT. The preliminary results showed that complexes 3d, 3f, 3h have significant inhibition on proliferation of three carcinoma cells such as MCF-7, HeLa and A549 cells, which were more active than cisplatin. Further mechanistic studies indicated that the tested complex 3h arrested the cell cycle in the S phase and can disrupted mitochondrial membrane potential and induced tumor cell apoptosis through reactive oxygen species (ROS)-dependent pathway.

A PERSONAL CARE COMPOSITION COMPRISING CURCUMINOIDS

The invention relates to a personal care composition comprising a compound of the curcuminoid class and to a process of preparing it. It has been shown to have anti-inflammatory benefit and can be utilised in a wide range of personal care products, while

METHODS AND FORMULATIONS FOR INCREASING CHEMICAL STABILITY AND BIOLOGICAL ACTIVITY OF PHENOLIC COMPOUNDS

The present teachings show that co-addition of a series of redox active antioxidants with diverse chemical structures dramatically increases the chemical stability of dietary phenolic compounds, enhanced their biological activities in cells, and boosted the circulating concentrations of these compounds in animal models.

Reactions of reactive oxygen species (ROS) with curcumin analogues: Structure-activity relationship

Three curcumin analogues viz., bisdemethoxy curcumin, monodemethoxy curcumin, and dimethoxycurcumin that differ at the phenolic substitution were synthesized. These compounds have been subjected for free radical reactions with DPPH radicals, superoxide radicals (O2?-?), singlet oxygen (1O2) and peroxyl radicals (CCl3O2 ?) and the bimolecular rate constants were determined. The DPPH radical reactions were followed by stopped-flow spectrometer, 1O2 reactions by transient luminescence spectrometer, and CCl3O 2? reactions using pulse radiolysis technique. The rate constants indicate that the presence of o-methoxy phenolic OH increases its reactivity with DPPH and CCl3O2?, while for molecules lacking phenolic OH, this reaction is very sluggish. Reaction of O2?-? and 1O2 with curcumin analogues takes place preferably at β-diketone moiety. The studies thus suggested that both phenolic OH and the β-diketone moiety of curcumin are involved in neutralizing the free radicals and their relative scavenging ability depends on the nature of the free radicals.

Synthesis and anti-inflammatory activity of some curcumin analogues

Curcumin (1) forms the diacetoxy (3) and dimethoxy (4) derivatives with acetic anhydride-pyridne and diazomethane, respectively.Friedel-Craft reaction of 1 with acetic anhydride and alkyl halides in the presence of anhydrous aluminium chloride affords the