55095-13-1

Upstream product

• 76005-94-2 2-chlorophenyl(phenyl)methanimine 
• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 
• 71225-69-9 (Z)-N-[(2-chlorophenyl)(phenyl)methylidene]hydroxylamine 

Downstream Products

• 94501-12-9 N-(2-chloro-ethyl)-N'-(3-chloro-benzhydryl)-urea 
• 117211-20-8 o-chlorobenzhydrylurea 
• 519175-62-3 N-[α-(2-chlorophenyl)phenylmethyl]-2,2-diethoxyacetamide 
• 88869-46-9 (3-chloro-benzhydryl)-(4,5-dihydro-oxazol-2-yl)-amine 
• 89721-02-8 1-(2-chlorophenyl)isoquinolin-3-ol 
• 519175-63-4 1-(2-chlorophenyl)isoquinolin-3-yl trifluoromethanesulfonate 

Relevant academic research and scientific papers

MODULATORS OF TREX1

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositons thereof, which are useful for treating a variety of conditions associated with TREX1.

Synthesis of N-methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)-isoquinoline-3-[11C]ca rboxamide ([11C-carbonyl]PK11195) and some analogues using [11C]carbon monoxide and 1-(2-chlorophenyl)isoquinolin-3-yl triflate

The benzodiazepine receptor ligand, N-methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide (PK11195), and five structurally related analogues were 11C-labelled via a palladium-mediated carbonylation using [11C]carbon monoxide, 1-(2-chlorophenyl)isoquinolin-3-yl trifluoromethanesulfonate and various amines. The 11C-labelled products were obtained with decay-corrected radiochemical yields in the range of 10-55% and with high specific radioactivity (e.g. 200-900 GBq μmol-1). The radiochemical purity of the final products exceeded 98%. In a typical experiment starting with 3.75 GBq [11C]carbon monoxide, 0.57 GBq of LC-purified products were obtained within 35 min of the start of the carbonylation reaction. For confirmation of the labelling position, N-(1-methylethyl)-1-(2-chlorophenyl)-isoquinoline-3-(13C)carboxamide was prepared and analysed by NMR. The precursor 1-(2-chlorophenyl)isoquinolin-3-yl trifluoromethanesulfonate was synthesised in five steps starting from 2-chlorobenzophenone. The precursor N-methyl-sec-butylamine was prepared from sec-butylamine by the reaction with ethyl chloroformate followed by reduction with LiAlH4. The non-radioactive reference compounds for the analogues were synthesised from 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid and the appropriate amines.

Substituted benzhydryl lactamimide derivatives

Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula SPC1 Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R1 may be the same or different