55095-65-3

Basic information

• Product Name: Benzoic acid, 5-chloro-2-[(4-chloro-2-nitrophenyl)amino]-
• CAS NO: 55095-65-3
• Molecular Formula: C13H8Cl2N2O4
• Molecular Weight: 327.124
• Mol File: 55095-65-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-chloro-2-[(4-chloro-2-nitrophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-chloro-2-[(4-chloro-2-nitrophenyl)amino]-(55095-65-3)
• EPA Substance Registry System: Benzoic acid, 5-chloro-2-[(4-chloro-2-nitrophenyl)amino]-(55095-65-3)

Safety Data

• Hazardous Substances Data: 55095-65-3(Hazardous Substances Data)

Upstream product

• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 635-21-2 5-chloroanthranilic acid 

Downstream Products

• 55051-43-9 5-Chlor-2-(2-amino-4-chlorphenylamino)-benzoesaeure 

Relevant articles and documents

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor

Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered (S)-3 as Clozapine-like dopamine D2/D1 receptor selectivity and improved reactive metabolites formation profile by the modification of piperazine moiety in Clozapine. The optimization of (S)-3 gave compound 5 to be best compound (approximately 10-fold stronger affinity for D2/D1 receptor and similar D2/D1 selectivity ratio with Clozapine). Clozapine-like D2/D1 receptor occupancy profile was proved by in vivo evaluation. In addition, the reactive metabolites derived agranulocytosis risk of compound 5 was considered to be lower than Clozapine. The pharmacology detail of compound 5 is being investigated to develop it for TRS treatment.