55117-15-2

Basic information

• Product Name: 2-Chloro-6-fluorobenzyl chloride
• Synonyms: 2-CHLORO-6-FLUOROBENZYL CHLORIDE;1-CHLORO-2-(CHLOROMETHYL)-3-FLUOROBENZENE;AKOS BBS-00004004;LABOTEST-BB LT02085021;Benzene, 1-chloro-2-(chloromethyl)-3-fluoro-;2-Chloro-6-Fluorochlorobenzyl;alpha,2-Dichloro-6-fluorotoluene;2,α-dichloro-6-fluorotoluene
• CAS NO: 55117-15-2
• Molecular Formula: C₇H₅Cl₂F
• Molecular Weight: 179.02
• EINECS: 259-487-5
• Product Categories: Fluorine series
• Mol File: 55117-15-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 7 °C
• Boiling Point: 208-210 °C
• Flash Point: 200 °F
• Appearance: clear colorless liquid
• Density: 1.401 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.441mmHg at 25°C
• Refractive Index: n20/D 1.537(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Lachrymatory
• BRN: 386840
• CAS DataBase Reference: 2-Chloro-6-fluorobenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-fluorobenzyl chloride(55117-15-2)
• EPA Substance Registry System: 2-Chloro-6-fluorobenzyl chloride(55117-15-2)

Safety Data

• Hazard Codes: C,Xi,N
• Statements: 34-51/53
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• TSCA: T
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 55117-15-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

2-Chloro-6-fluorobenzyl chloride was used:as alkylating reagent during the synthesis of 3-benzylsulfanyl derivatives of 1,2,4-triazole and 4-methyl-1,2,4-triazolein the preparataion of 2-chloro-6-fluorobenzylamine, required for the synthesis of 9-substituted adeninein the preparation of aprinocid via reaction with adenine

InChI:InChI=1/C8H9Cl/c1-7-4-2-3-5-8(7)6-9/h2-5H,6H2,1H3

Upstream product

• 443-83-4 2-chloro-6-fluorotoluene 
• 56456-50-9 (2-chloro-6-fluorophenyl)methanol 

Downstream Products

• 70091-23-5 9-(2-chloro-6-fluorobenzyl)-6-dimethylaminopurine 
• 70091-21-3 9-(2-chloro-6-fluorobenzyl)-6-methylaminopurine 
• 190521-88-1 diethyl (2-chloro-6-fluoro-phenyl)-malonate 
• 151411-26-6 3-(2-chloro-6-fluoro-benzyloxy)-pyridin-2-ylamine 
• 888739-50-2 3-[1-(2-chloro-6-fluorobenzyl)-3-isopropoxy-1H-pyrazole-5-yl]propionic acid ethyl ester 
• 325959-09-9 2-[2-(2-chloro-6-fluoro-benzylsulfanyl)-phenyl]-1,4,5,6-tetrahydro-pyrimidine; hydrochloride 
• 380426-11-9 2-chloro-6-[4-[1-(2-chloro-6-fluorobenzyl)]piperidinylamino]-9-cyclopentylpurine 
• 380424-71-5 4-amino-1-(2-chloro-6-fluorobenzyl)piperidine 
• 713518-29-7 1-(2-chloro-6-fluoro-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 380424-18-0 1-(2-chloro-6-fluoro-benzyl)-piperidine-4-carboxylic acid amide 

Relevant articles and documents

[4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia

[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1and Y2are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.

Synthesis of 1-methyl-1-(substituted benzyl)hydrazines.

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