55118-88-2Relevant academic research and scientific papers
Uses of dimedone to synthesis pyrazole, isoxazole and thiophene derivatives with antiproliferative, tyrosine kinase and Pim-1 kinase inhibitions
Abdelwahab, Amal,Mahmoud, Mahmoud Ali Abdelaziz,Manhi, Fatma Mohamed,Mohareb, Rafat Milad
, (2020)
We are aiming in this work to synthesize target molecules not only possess antitumor activities but also kinase inhibitors. The target molecules were obtained from dimedone, which reacted with triethoxymethane to produce a product that is capable for many heterocyclization reactions to give fused pyrazole, thiophene and isoxazole derivatives. Compounds 7b, 7c, 7d, 9b, 11, 12c, 12d, 14b, 16b, 17c, 17d, 18c, 18d, and 18e were the most cytotoxic compounds, their further tests toward the five tyrosine kinases c-Kit, Flt-3, VEGFR-2, EGFR, and PDGFR and Pim-1 kinase showed that compounds 7b, 7d, 11, 12c, 14b, 16b, 17d, 18d, and 18e were the most potent of the tested compounds toward the five tyrosine kinases and compounds 7b, 7d, 14b, 16b, and 18e were of the highest inhibitions toward Pim-1 kinase. PAINS the most cytotoxic compounds showed zero PAINS alert, therefore, these compounds can be used as useful drugs in the future.
Ultrasound assisted regioselective synthesis, photophysical and structural studies of 1-substituted indazol-4(5H)-ones and enaminodiketones of dimedone
Chaudhary, R. P.,Gautam, Deepika,Gautam, Poonam,Mittal, Isha
, (2020/12/23)
Enaminodiketone, obtained from reaction of dimedone with DMF-DMA, on reaction with nucleophiles such as amines, guanidine hydrochloride and substituted aromatic hydrazines furnished enaminodiketones, quinazolines and indazole derivatives respectively. The
Metal-free coupling/isomerization reaction of isocyanide and cyclic 1,3-dione: A selective Csp3-H functionalization strategy for C-C bond formation
Jiang, Hui,Li, Jian,Li, Yefei,Sun, Mingming,Yao, Jun
supporting information, (2020/08/28)
A metal-free oxidative coupling/isomerization reaction of isocyanide and cyclic 1, 3-dione has been disclosed. In the presence of di-tert-butylperoxide (DTBP), a series of isocyanides are subjected to reaction with subsituted 1, 3-diones for direct synthe
