55143-08-3Relevant academic research and scientific papers
Search for anxiolytic activity starting from a myorelaxant structure. tert Butylphenol derivatives
Auzou,Rips,Derappe,Peyroux
, p. 548 - 554 (2007/10/07)
Twenty eight compounds (10 phenoxypropanediols, 9 epoxides and 9 phenoxymethyloxazolidinones carrying on the benzene ring 1 or 2 tert. butyl groups and sometimes an allyl group) were investigated for myorelaxant and anxiolytic activities. These actions can be dissociated; 2 compounds - 5[(2 tert butylphenoxy)methyl]oxazolidin 2 one (R 1297) and 5 [(2 allyl 5 tert. butylphenoxy)methyl]oxazolidin 2 one (R 1377) - lack the former while being very effective in the 4 plate and electric battle tests. They have no sedative action and are virtually devoid of toxicity.
