55149-74-1

Usage

Chemical compound

2-Propenamide, 2-cyano-3-(3,4-dimethoxy-2-nitrophenyl)-

Physical state

Yellow solid

Primary use

Building block in the synthesis of pharmaceutical and agrochemical compounds

Additional uses

Production of dyes and pigments

Contains

Cyano group and nitro group

Potential applications

Development of new drugs and other chemical products

Important note

Handle with care due to potential toxic and hazardous properties

Upstream product

• 55149-84-3 2-nitroveratraldehyde 
• 107-91-5 cyanoacetic acid amide 

Relevant academic research and scientific papers

Structure-Activity Relationships in a Series of Novel 3,4-Dihydro-4-oxopyrimidoquinoline-2-carboxylic Acid Antiallergy Agents

A series of more than 50 new 3,4-dihydro-4-oxopyrimidoquinoline-2-carboxylic acid derivatives and related compounds with substituent variations at the 2, 3, and 5-9 positions was prepared and evaluated for antiallergy activity using the rat PCA assay.These compounds were obtained by the condensation of the appropriately substituted 2-aminoquinoline-3-carboxamides with dialkyl oxalates, followed by further chemical transformations.More than two-thirds of the compounds prepared exhibited intravenous activity ranging from 1 to 400 times disodium cromoglycate (DSCG).Structure-activity data suggest that the presence of a carboxylic acid moiety at the 2 position affords optimal potency and that esters are preferred for good oral absorption.Best oral activity, with ED50 values ranging from 0.3 to 3.0 mg/kg, was displayed by ethyl esters with methoxy and/or ethoxy groups at the 7 and 8 positions.