55150-29-3Relevant articles and documents
Chemoselective Synthesis of N -(Aminoalkyl/amidino)phenyl Naphthalene-1-carboxamides and 5,6,7,8-Tetrahydronaphthalene-1-carboxamides and Their Anticoagulant Screening
Nguyen, Thi Ha,Ma, Eunsook
, p. 2660 - 2664 (2017)
N -[(Aminoalkyl)phenyl]-1-naphthamides and N -[(aminoalkyl)phenyl]-5,6,7,8-tetrahydronaphthalene-1-carboxamides were selectively synthesized from the corresponding cyanonaphthamides by catalytic hydrogenation. N -(Amidinophenyl)-1-naphthalenecarboxamides and N -(amidinophenyl)-5,6,7,8-tetrahydronaphthalene-1-carboxamides were chemoselectively obtained from the corresponding O -acetylamidoximes or amidoximes, respectively, by catalytic hydrogenation. The products were screened for their anticoagulant effects in human plasma, as measured by the activated partial thromboplastin time and the prothrombin time in vitro. Amidines and 5,6,7,8-tetrahydronaphthamides were more active than aminoalkyl compounds and naphthamides.
A preparation method of naphthalene husband xilin acid
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Paragraph 0025; 0026; 0044; 0050, (2017/10/05)
The invention discloses a method for preparing nafcillin acid. The method comprises the following steps: (1) chlorinating 2-ethoxy naphthoic acid and excessive amount of sulfoxide chloride to obtain an acyl chloride solution; carrying out distillation at reduced pressure to remove sulfoxide chloride, dissolving residues with dichloromethane, and thus obtaining a mixed solution A; (2) adding triethylamine and dichloromethane in 6-aminopenicillanic acid, stirring until the solution is clear, and thus obtaining a mixed solution B; (3) dropwise adding the mixed solution A in the mixed solution B for condensation reaction, carrying out thermal reaction for 30-90 min after the mixed solution A completely is dropwise added in the mixed solution B, and thus obtaining a mixed solution C; (4) concentrating the mixed solution C to be dry, and thus obtaining a solid mixture D; (5) stirring and dispersing the solid mixture D with a ketone reagent, acidizing with an acidifier, adding an ether reagent to stir, filtering, adding purified water or saturated salt water in filtrate to crystallize, filtering, washing with water, drying, and thus obtaining nafcillin acid. The method has the advantages of being simple in process, easy to operate, simple in postprocessing and high in yield.
