55152-72-2

Usage

Uses

Used in Hepatitis Treatment:
AMSA is utilized as an antiviral agent for the treatment of chronic hepatitis B and C. It functions by inhibiting the viral replication process, specifically targeting the polymerase enzyme, which is crucial for the replication of hepatitis B and C viruses.
Used in Cancer Therapy:
AMSA is also under investigation for its potential use in cancer therapy. It has demonstrated promising results in inhibiting the growth of cancer cells by interfering with their cell cycle and promoting apoptosis. However, further research is necessary to fully comprehend its therapeutic potential and to evaluate any possible side effects associated with its use in cancer treatment.

Upstream product

• 534-13-4 N,N-dimethylthiourea 

Relevant academic research and scientific papers

Reactive oxygen species in aerobic decomposition of thiourea dioxides

Thiourea dioxides decompose in air-saturated alkaline solutions to give dithionite, S2O42-. Kinetics of decomposition of aminoiminomethanesulfinic acid (AIMSA), methylaminoiminomethanesulfinic acid (MAIMSA) and dimethylaminoiminomethanesulfinic acid (DMAIMSA) were studied in alkaline solutions under aerobic and anaerobic conditions. No dithionite was formed in strictly anaerobic conditions. Dithionite, however, was formed in the presence of KO2 and H2O2 under anaerobic conditions. The rate of decomposition was fastest for DMAIMSA and slowest for MAIMSA. The proposed mechanism involves the initial formation of the dioxosulfate(2-) ion, SO22-, through the heterolytic cleavage of the C-S bond. The dioxosulfate(2-) ion then reacts with dioxygen to give a series of reactive oxygen species: Superoxide, peroxide and the hydroxyl radical. The expected dismutation of Superoxide is important only in weakly alkaline solutions of pH less than 10. It is suggested, for the first time, that the reactive oxygen species and the sulfur leaving groups may be responsible for the toxicity observed in most thioureas. The Royal Society of Chemistry 2000.