55179-23-2

Upstream product

• 52575-96-9 1-(4-bromo-phenoxy)-3,3-dimethyl-1-[1,2,4]triazol-1-yl-butan-2-one 

Downstream Products

• 69357-17-1 1-[2-allyloxy-1-(4-bromo-phenoxy)-3,3-dimethyl-butyl]-1H-[1,2,4]triazole 
• 95059-90-8 1-[(E)-1-(4-Bromo-phenoxy)-3,3-dimethyl-but-1-enyl]-1H-[1,2,4]triazole 
• 83724-24-7 1-[(E)-1-(4-Bromo-phenoxy)-3,3-dimethyl-but-1-enyl]-1H-[1,2,4]triazole 
• 83338-72-1 Toluene-4-sulfonic acid 1-[(4-bromo-phenoxy)-[1,2,4]triazol-1-yl-methyl]-2,2-dimethyl-propyl ester 

Relevant academic research and scientific papers

A Facile Synthesis of Ketene O,N-Acetals and Ketene O,O-Acetals by Tosylate Elimination

Reaction of the alcohols 4 and 5 with p-toluensulfonyl chloride leads to the sulfonic esters 6 and 7, respectively, which on treatment with potassium tert-butylate easily react to give the ketene O,N-acetals 8 and O,O-acetals 9, respectively.The (E/Z) isomers 8 arising from the elimination reaction of 7 were identified by their 1H-NMR data after X-ray analysis of one of the isomers of 8e.On one example it is shown that the elimination reaction proceeds stereoselectively "anti".

Compositions containing O,N-acetal and method of using same

Pharmaceutical compositions comprising a triazolyl-O,N-acetal as the active ingredient and method of using same. The said compositions are useful as antimicrobials and are especially useful as antimycotic agents.