5518-91-2Relevant academic research and scientific papers
A New Method for Thiomethylation of Hydroxy-1,4-naphthoquinones with N -Acetyl- l -cysteine; First Synthesis of Fibrostatins B, C, and D
Sabutskii, Yuri E.,Polonik, Sergey G.,Denisenko, Vladimir A.,Dmitrenok, Pavel S.
, p. 2763 - 2770 (2015/02/19)
A series of N-acetyl-S-[(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl]-l-cysteine conjugates were obtained in good yields by acid-catalyzed condensation of substituted 2-hydroxy-1,4-naphthoquinones with N-acetyl-l-cysteine and paraformaldehyde. Based on this reaction, a first synthesis of fibrostatins B, C, and D was developed.
REACTIONS OF KETENE ACETALS-14; THE USE OF SIMPLE MIXED VINYLKETENE ACETALS IN THE ANNULATION OF QUINONES
Savard, Jacques,Brassard, Paul
, p. 3455 - 3464 (2007/10/02)
α,β- and β,γ-unsaturated esters can be converted by strong base and chlorotrimethylsilane to the corresponding mixed vinylketene acetals which are shown to be particularly useful and generally applicable reagents for the regiospecific annulation of halogenoquinones.The reaction proceeds readily with a variety of substrates including benzoquinones.
