55186-89-5

Usage

Uses

1-Benzyl-1,4-diazepan-5-one is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, particularly those with potential therapeutic applications.
Used in Pharmaceutical Industry:
1-Benzyl-1,4-diazepan-5-one is used as a diazepane intermediate for the development of novel drugs targeting specific medical conditions.
Used in Inhibitor Applications:
1-Benzyl-1,4-diazepan-5-one is used as an inhibitor of human nitric oxide synthesis, which can be beneficial in the treatment of conditions where nitric oxide overproduction is a concern, such as certain inflammatory diseases or cardiovascular disorders. By inhibiting nitric oxide synthesis, 1-Benzyl-1,4-diazepan-5-one may help regulate the balance of this important signaling molecule in the body, potentially leading to improved patient outcomes.

InChI:InChI=1/C12H16N2O/c15-12-6-8-14(9-7-13-12)10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H,13,15)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 949-69-9 N-benzyl-4-(N-hydroxyimino)piperidine 

Downstream Products

• 4410-12-2 1-benzyl-[1,4]diazepane 
• 214911-30-5 (4-benzyl-7-oxo-[1,4]diazepan-1-yl)-acetic acid ethyl ester 
• 34376-54-0 [1,4]diazepan-5-one 
• 214911-33-8 (7-oxo-4-phenylmethanesulfonyl-[1,4]diazepan-1-yl)-acetic acid 
• 214911-32-7 ethyl 2-(4-benzylsulfonyl-7-oxo-1,4-diazepan-1-yl)acetate 
• 214911-34-9 C₃₀H₃₇N₇O₇S₃ 
• 477740-02-6 1-Benzyl-4-(4-bromo-phenyl)-[1,4]diazepan-5-one 
• 190900-21-1 5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

NOVEL TRIAZINE COMPOUNDS

The present invention relates to novel triazine compounds of formula (1). The present invention also discloses compounds of formula I along with other pharmaceutical ac-ceptable excipients and use of the compounds to modulate the PI3K/ mTOR pathway

NOVEL TRIAZINE COMPOUNDS

The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/ or the mTOR pathway.

PYRAZOLE DERIVATIVE

Not available

2-chloro-1,3-dimethylimidazolinium chloride. 3. Utility for chlorination, oxidation, reduction, and rearrangement reactions

2-Chloro-1,3-dimethylimidazolinium chloride (1), which can act as a powerful dehydrating equivalent to DCC (2), is also applicable to chlorination, oxidation, reduction, and rearrangement under nearly neutral conditions. The utility of 1 for these reactions is described.

New synthesis of (±)-2-piperazinecarboxylic acid

(±)-2-Piperazinecarboxylic acid is prepared from N-carbethoxy-4-piperidone by α Schmidt rearrangement followed by bromation of the lactam; then α Favorskii rearrangement on the monobromolactam intermediate afforded the desired product.