551908-51-1Relevant academic research and scientific papers
Synthesis of a novel class of fatty acids-derived isoquinolines
Matuszewska, Iwona,Leniewski, Andrzej,Roszkowski, Piotr,Czarnocki, Zbigniew
, p. 131 - 145 (2005)
Two series of novel tetrahydroisoquinoline derivatives bearing at C-1 position a carbon chain derived from fatty acids were prepared employing two complementary synthetic methodologies. The Pictet-Spengler condensation was performed on myristyl, palmityl, stearyl and oleyl aldehydes, whereas the Bischler-Napieralski cyclization used pelargonic, stearic, linolenic and arachidonic acids. The ability to apply both methods allows further labeling of the final 1-substituted-1,2,3,4-tetrahydroisoquinolines for biological studies.
Synthesis of 1-alkyltetrahydroisoquinolines
Saidov,Levkovich,Vinogradova
, p. 897 - 901 (2014/01/17)
1-Alkyltetrahydroisoquinolines were prepared by a Bischler-Napieralski reaction starting from homoveratrylamine and monobasic acids. Their structures were confirmed by IR and NMR spectral data.
