551919-98-3Relevant academic research and scientific papers
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors
Stevens, Kirk L.,Reno, Michael J.,Alberti, Jennifer B.,Price, Daniel J.,Kane-Carson, Laurie S.,Knick, Victoria B.,Shewchuk, Lisa M.,Hassell, Anne M.,Veal, James M.,Davis, Stephen T.,Griffin, Robert J.,Peel, Michael R.
scheme or table, p. 5758 - 5762 (2009/06/18)
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3β.
PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS
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Page 50, (2008/06/13)
The present invention relates generally to inhibitors of the kinases, such as GSK3, and more particularly to fused pyradazine compounds according to formula (I) and methods of their use.
