551920-31-1Relevant academic research and scientific papers
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors
Stevens, Kirk L.,Reno, Michael J.,Alberti, Jennifer B.,Price, Daniel J.,Kane-Carson, Laurie S.,Knick, Victoria B.,Shewchuk, Lisa M.,Hassell, Anne M.,Veal, James M.,Davis, Stephen T.,Griffin, Robert J.,Peel, Michael R.
, p. 5758 - 5762 (2008)
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3β.
