55198-79-3

Basic information

• Product Name: 4-(dimethylamino)-N-(4-methoxyphenyl)benzamide
• Synonyms: 4-(dimethylamino)-N-(4-methoxyphenyl)benzamide
• CAS NO: 55198-79-3
• Molecular Weight: 270.331
• Mol File: 55198-79-3.mol

Chemical Properties

• CAS DataBase Reference: 4-(dimethylamino)-N-(4-methoxyphenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dimethylamino)-N-(4-methoxyphenyl)benzamide(55198-79-3)
• EPA Substance Registry System: 4-(dimethylamino)-N-(4-methoxyphenyl)benzamide(55198-79-3)

Safety Data

• Hazardous Substances Data: 55198-79-3(Hazardous Substances Data)

Upstream product

• 10076-13-8 N,N'-bis(4-methoxyphenyl)carbodiimide 
• 15024-12-1 phenyl 4-(N,N-dimethylamino)benzoate 
• 104-94-9 4-methoxy-aniline 
• 4755-50-4 4-(dimethylamino)benzoyl chloride 

Downstream Products

• 82020-41-5 4-dimethylamino-N-(4'-methoxyphenyl)-benzenecarbothiamide 
• 10205-71-7 4-(6-methoxybenzo[d]thiazol2-yl)-N,N-dimethylaniline 

Relevant articles and documents

Nickel-catalyzed reductive amidation of aryl-triazine ethers

The reaction of activated phenolic compounds, 2,4,6-triaryloxy-1,3,5-triazine (aryl-triazine ethers), with various isocyanates or carbodiimides in the presence of a nickel pre-catalyst resulted in the synthesis of aryl amides in good to excellent yields.

A Cross-Coupling Approach to Amide Bond Formation from Esters

A palladium-catalyzed cross-coupling between aryl esters and anilines is reported, enabling access to diverse amides. The reaction takes place via activation of the C-O bond by oxidative addition with a Pd-NHC complex, which enables the use of relatively non-nucleophilic anilines that otherwise require stoichiometric activation with strong bases in order to react. High yields of aromatic, aliphatic, and heterocyclic products are obtained. A range of activated esters are evaluated in the presence and absence of catalyst, demonstrating that the catalytic methodology substantially increases the types of electrophiles that can be utilized for amide bond formation in the absence of harsh bases.

Synthesis of 2-arylbenzothiazoles by DDQ-promoted cyclization of thioformanilides; a solution-phase strategy for library synthesis

Several substituted benzothiazoles were synthesized by the intramolecular cyclization of thioformanilides using 2,6-dichloro-3,5-dicyano-1,4-benzoquinone (DDQ) in dichloromethane at ambient temperature in high yields. The resulting 2-arylbenzothiazoles we

Synthesis and analgesic activity in 1,2,4-triazole series

Derivatives of 1,2,4-triazole have been synthesized. Several methods of synthesis were used and the analgetic and antiinflammatory properties of the products obtained were studied. Structural requirements for analgetic activity were specified. Certain compounds show a high degree of analgetic activity. One of them, RU 39813, has been chosen for extended pharmacological study.