55199-24-1

Usage

Uses

Used in Pharmaceutical Industry:
6,7-Dimethylindole is used as an intermediate in the synthesis of pharmaceuticals for its potential biological and pharmacological activities, including its antitumor properties and its ability to inhibit cancer cell growth.
Used in Dye and Pigment Industry:
This chemical compound is utilized as an intermediate in the production of dyes and pigments, contributing to the coloration and stability of various products.
Used in Chemical Analysis:
6,7-Dimethylindole serves as an indicator in chemical analysis, playing a crucial role in the identification and quantification of substances in laboratory settings.
Used in Organic Synthesis:
As a reagent, 6,7-Dimethylindole is employed in organic synthesis to facilitate a range of chemical reactions, broadening its applications across different industries.

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 107-21-1 ethylene glycol 
• 87-59-2 2,3-Dimethylaniline 

Downstream Products

• 480435-98-1 3-(6,7-dimethyl-1H-indol-3-yl)-2,5-dichloro[1,4]benzoquinone 

Relevant academic research and scientific papers

β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction

Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely been achieved. Herein, a combination of Pd/C and ZnO is reported as heterogeneous catalyst for this BH/HA reaction. This system results in an extremely air and moisture stable, and economic catalyst able to mono-functionalize ethylene glycol in water, without further activation of the diol. In this work, different diols and aromatic amines have been explored affording a new approach towards amino alcohols. This study reveals how the combination of two solid species can afford interesting catalytic properties in heterogeneous phase. ZnO activates ethylene glycol while Pd/C is the responsible of the BH/HA cycle. This catalytic system has also been found useful to dehydrogenate indoles affording indolines that undergo in situ BH/HA cycle prior to re-aromatization, representing a tandem heterogeneous process.

4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents

This invention relates to certain 4-aminoquinazolines and the pharmaceutically acceptable salts and stereoisomers thereof, the formula whereof are described herein. The compounds are useful for the treatment of hyperproliferative diseases, particularly as anti-cancer agents.