55211-09-1

Basic information

• Product Name: 3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-1-(3-dimethylamino-propyl)-1H-quinazoline-2,4-dione
• CAS NO: 55211-09-1
• Molecular Weight: 484.041
• Mol File: 55211-09-1.mol

Chemical Properties

• CAS DataBase Reference: 3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-1-(3-dimethylamino-propyl)-1H-quinazoline-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-1-(3-dimethylamino-propyl)-1H-quinazoline-2,4-dione(55211-09-1)
• EPA Substance Registry System: 3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-1-(3-dimethylamino-propyl)-1H-quinazoline-2,4-dione(55211-09-1)

Safety Data

• Hazardous Substances Data: 55211-09-1(Hazardous Substances Data)

Relevant articles and documents

Derivatives of 1,3 disubstituted 2,4(1H,3H)-quinazolinediones as possible peripheral vasodilators or antihypertensive agents

A series of 1,3-disubstituted 2,4(1H,3H)-quinazolinediones was prepared from the 3-substituted 2,4(1H,3H)-quinazolinediones by treatment with sodium hydride and the desired alkyl halide in xylene. These compounds showed varying degrees of vasodilation and antihypertensive activity without significant blockade of α-adrenergic receptors. 1-[3-(N,N-dimethylamino)propyl]-3-[3-(4-phenyl-1-piperazinyl)propyl]-2,4(1H,3H)-quinazolinedione, which was selected for further studies, was more potent than papaverine in inducing vasodilation and induced a prolonged decrease in systolic blood pressure of hypertensive rats upon oral administration.